Chronic kidney disease is one of the most prevalent chronic conditions worldwide, affecting over 10% of the global population. This multifactorial disease, characterized by a diverse range of etiologies and histopathologies, progresses relentlessly, often culminating in kidney failure. When chronic kidney disease reaches this critical stage, life-sustaining interventions such as dialysis and transplantation become necessary.

The primary causes of chronic kidney disease are diabetes and hypertension, with current therapies largely focusing on managing blood pressure and glycemia based on the underlying etiology. However, conditions like glomerulopathy and rare genetic disorders frequently resist conventional treatments, highlighting the pressing need for more effective and targeted therapies. Despite significant advances in chronic kidney disease management that have improved kidney survival rates and patient quality of life, certain patient subgroups—especially those with cardiovascular risks, rapidly progressing kidney disease, inflammatory conditions, or those in the late stages of the disease—continue to represent an unmet clinical need.

This Research Topic seeks to explore and disseminate new strategies aimed at controlling the progression of chronic kidney disease. We invite submissions that span basic, translational, and clinical research, with a focus on the following areas:

• Identification of new specific targets for therapy;

• Validation of novel biomarkers and diagnostic tools;

• Therapeutic and diagnostic approaches based on nanotechnology;

• Gene silencing therapies;

• Immunotherapy strategies;

• Development and application of monoclonal and multispecific antibodies.

The integration of technological advancements, such as omics and computational tools, has revolutionized our understanding of chronic kidney disease by uncovering novel mechanisms and genetic factors involved in its pathophysiology. These discoveries are paving the way for precision medicine approaches and targeted drug delivery, which promise to usher in a new era of chronic kidney disease management. In transplantation, these techniques offer opportunities to apply precision medicine strategies to reduce the risk of organ failure, further enhancing patient outcomes.

Nanotechnology, in particular, holds immense potential for revolutionizing chronic kidney disease treatment by enabling targeted drug delivery to specific compartments of the kidney or diseased sites, thereby reducing adverse effects and increasing treatment efficacy. Precision medicine, grounded in accurate diagnosis and tailored interventions, has already demonstrated success in managing autoimmune kidney diseases, glomerulonephritis, and onconephrology.

We encourage researchers, academics, and clinicians from diverse disciplines to contribute to this Research Topic. By bringing together expertise from various fields, we aim to foster a multidisciplinary dialogue that will drive innovation and improve outcomes for patients with chronic kidney disease.

We welcome all types of contributions, including original research articles, reviews, case reports, and commentaries. Submissions should align with the outlined focus areas and contribute to advancing our understanding and management of chronic kidney disease.

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Frontiers in Nephrology

Submit your idea

Impact