The field of digestive system cancer research is witnessing a significant rise in immune-related cases, which are increasingly affecting patients' quality of life and overall health. The progression and metastasis of these cancers are particularly challenging due to the complex interplay between the tumor microenvironment and immune response mechanisms. These diseases are characterized by intricate pathophysiological processes, such as abnormal immune system activation and chronic inflammation. Recent advancements in molecular biology and immunology have shed light on these mechanisms, paving the way for novel therapeutic strategies. Despite the availability of traditional treatments like chemotherapy and radiotherapy, their side effects and long-term effectiveness remain contentious. Emerging therapies, including immunotherapy and targeted treatments, offer new hope, especially for patients with metastatic conditions. However, the challenge of creating precise, individualized treatment plans persists. The integration of multidisciplinary collaboration and personalized treatment strategies is gaining traction as a promising approach to enhance treatment outcomes and prognosis, marking a pivotal area of focus in current research and clinical practice.

This research topic aims to consolidate the latest treatment methods and techniques for immune-related digestive system cancers, evaluate the clinical outcomes and prognoses of various treatment approaches, delve into the molecular mechanisms and biomarkers associated with immune factors in cancer progression, and disseminate successful case studies and lessons to elevate clinical treatment standards.

To gather further insights in the clinical advances and practice of digestive system cancer progression and metastasis induced by immune factors, we welcome articles addressing, but not limited to, the following themes:
- Epidemiology and Pathophysiology: Investigate the roles and influencing factors of immune factors in digestive system cancer.
- Latest Treatment Techniques: Discuss immunotherapy, targeted therapy, and their indications and limitations.
- Molecular Mechanisms and Biomarkers: Explore molecular mechanisms and potential biomarkers for precision medicine.
- Multidisciplinary Collaborative Treatment Models: Share experiences and successful cases from multidisciplinary teams.
- Personalized Treatment Strategies: Develop and evaluate individualized treatment plans based on patient conditions.
- Typical Case Analysis: Present representative cases for detailed analysis and lessons learned.
- Rare Case Reports: Document rare cases, discussing their uniqueness and treatment challenges.

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Frontiers in Cell and Developmental Biology

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