About this Research Topic
Cardiovascular diseases are the leading cause of death in the world. In recent years, several studies have shown some pathophysiological processes that favor the development or progression of cardiovascular diseases, such as: inflammation, increased reactive oxygen species, apoptosis and fibrosis. However, many molecular mechanisms associated with these pathophysiological processes still need to be elucidated. On the other hand, physical exercise is considered an important non-pharmacological tool to attenuate these pathophysiological processes and improve cardiovascular function, in addition to modulating the expression of many genes, non-coding RNAs and proteins, promoting beneficial adaptations in the cardiovascular system.
Understanding these mechanisms will enable the creation of new treatments, and these molecules may serve as new biomarkers for diagnosis and targeted gene therapy. Therefore, this Frontiers Research Topic is focused on articles that can elucidate dysregulated pathophysiological and molecular processes in cardiovascular and metabolic diseases, as well as articles that evaluate the response to physical exercise for these diseases. We encourage the submission of original articles, reviews and mini-reviews. Clinical data will be appreciated and considered for publication if supported by studies on the underlying physiological and pathophysiological mechanisms. Please note that clinical trials and case reports cannot be submitted to Integrative Physiology.
Understanding these mechanisms will enable the creation of new treatments, and these molecules may serve as new biomarkers for diagnosis and targeted gene therapy. Therefore, this Frontiers Research Topic is focused on articles that can elucidate dysregulated pathophysiological and molecular processes in cardiovascular and metabolic diseases, as well as articles that evaluate the response to physical exercise for these diseases. We encourage the submission of original articles, reviews and mini-reviews. Clinical data will be appreciated and considered for publication if supported by studies on the underlying physiological and pathophysiological mechanisms. Please note that clinical trials and case reports cannot be submitted to Integrative Physiology.
Keywords: non-coding RNAs, cardiovascular, metabolic, biomarkers, exercise
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
