Drug-coated balloons (DCB) have recently garnered significant attention and acceptance in the realm of interventional cardiology. These innovative devices are increasingly utilized, predominantly supported by data derived from the treatment of in-stent restenosis and small coronary vessels. Despite their growing use, considerable gaps remain in our understanding of their performance in larger coronary vessels and more complex lesions. Critical aspects such as optimal lesion preparation and the long-term outcomes following treatment with different DCB formulations, such as limus-coated balloons, remain inadequately explored.

This Research Topic aims to gather comprehensive insights into the multifaceted applications of DCB in both acute and chronic CAD management. We welcome all article types that explore various dimensions of DCB use, aiming to fill current knowledge gaps and advance clinical practice. By compiling high-quality research and clinical insights, we seek to inform and enhance interventional strategies, leading to better patient outcomes.

The scope of this Research Topic includes, but is not limited to:

1. Adjunctive and Antithrombotic Therapies:
o Studies focusing on adjunctive therapies following treatment with DCBs.
o Evaluation of antithrombotic therapy strategies in conjunction with DCB treatment.

2. Performance in Large Vessels and Complex Lesions:
o Comparative studies assessing DCB efficacy in large versus small coronary vessels.
o Outcomes and procedural success rates in complex coronary lesions treated with DCB.

3. Lesion Preparation Techniques:
o Optimal strategies for lesion preparation before DCB application.
o Impact of different preparation methods on DCB efficacy and safety.

4. Clinical Outcomes and Long-Term Efficacy:
o Short-term and long-term clinical outcomes following DCB treatment.
o Comparative efficacy of various DCB coatings, including paclitaxel and limus.

5. Mechanisms of Action and Pharmacokinetics:
o Studies elucidating the mechanisms through which DCB deliver therapeutic agents.
o Pharmacokinetic profiles of different drug coatings used in DCB.

6. Safety and Complications:
o Analysis of adverse events and complications associated with DCB use.
o Strategies to mitigate risks and enhance patient safety during and after DCB interventions.

7. Comparisons with Alternative Therapies:
o Head-to-head comparisons of DCB with other interventional techniques like drug-eluting stents (DES).
o Cost-effectiveness and health economics analyses comparing DCB with other CAD treatments.

8. Innovations and Future Directions:
o Cutting-edge research on next-generation DCB technologies.
o Future directions for clinical research and potential new applications of DCB.
o Studies focusing on adjunctive and antithrombotic therapies following treatment with DCBs

9. Adjunctive and Antithrombotic Therapies:
o Studies focusing on adjunctive therapies following treatment with DCBs.
o Evaluation of antithrombotic therapy strategies in conjunction with DCB treatment.

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Frontiers in Cardiovascular Medicine

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