The health and performance of poultry are critical to the productivity and profitability of the poultry industry. The liver is a key immune tissue that is ideally positioned to detect pathogens entering the body through the gut. The liver appears designed to detect, capture, and clear bacteria, viruses, and other pathogens. Containing the largest collection of phagocytic cells in the body, this organ is an important barrier between the host and the outside world. The balance between immunity and tolerance is essential to liver function. Excessive inflammation in the absence of infection leads to sterile liver injury, tissue damage, and remodeling, such that impaired immunity allows for chronic infection. The dynamic interactions between numerous populations of immune cells in the liver are key to maintaining this balance and overall tissue health. The gut which serves as the home to diverse microbiota, directly influences nutrient absorption and immune responses, while the liver processes these nutrients and detoxifies harmful substances. The liver and gut are interdependent organs that work synergistically to maintain homeostasis and overall health. The liver-gut axis plays a crucial role in various physiological processes, including digestion, metabolism, immunity, and detoxification. However, challenges such as infectious diseases, metabolic disorders, and suboptimal nutrition can disrupt this axis, leading to poor health and impaired performance in poultry. Understanding and enhancing the liver-gut functions through integrated approaches is essential for promoting poultry health and productivity.

The primary goal of this Research Topic is to gather cutting-edge research and reviews on the integrated approaches to enhance poultry health and productivity by promoting liver-gut functions. This collection aims to provide a comprehensive understanding of the physiological, nutritional, genetic, and immunological interactions within the liver-gut axis and to identify innovative strategies and biomarkers to optimize these functions for improved poultry production outcomes. Therefore, in this Research Topic, we aim to advance the knowledge of liver-gut interactions in poultry, promote innovative strategies to enhance health and performance, and ultimately contribute to the sustainability and productivity of the poultry industry.

In this Research Topic, we welcome authors to submit Original Research, Comprehensive Reviews, Mini-reviews, Perspective, and Clinical Trial articles that cover research advances in the following areas, including but not limited to:

a. Studies on the interactions and mechanisms of action governing the liver-gut axis in poultry.

b. Research on the environmental, nutritional, immunological, genetic, and molecular factors influencing liver and gut functions in poultry.

c. Impacts of various flavonoids, vitamins, amino acids, macro and micronutrients on alleviating liver-gut dysfunctions/disorders.

d. Studies on novel mechanisms through which dietary supplements attenuate liver-gut autoimmunity and mortality in poultry species.

e. Research on the mechanisms of nutrient absorption and metabolism in the liver-gut axis.

f. Investigations into the liver's role in detoxification and its impact on the gut health of poultry.

g. Studies on the role of probiotics, prebiotics, and synbiotics modulating gut microbiota and liver health, focusing on their immunological, physiological and metabolic roles in poultry.

h. Studies on the potential influence of embryonic gut microbiota manipulation (in ovo stimulation) to promote overall health and performance of poultry species.

i. Strategies to alleviate the effects of antibiotic resistance/disease resistance through liver-gut axis modulation in poultry.

j. Emerging technologies for diagnosing, monitoring, and improving liver and gut functions in poultry species

We encourage researchers, academicians, and industry professionals to submit original research articles, reviews, mini-reviews, and case studies that align with the scope of this Research Topic. Submissions should provide novel insights, methodological advancements, or comprehensive reviews that contribute to the understanding and enhancement of liver-gut functions in poultry. Collaborative studies that integrate physiology, nutrition, immunology, and genetics are highly welcomed. Potential authors should ensure that their manuscripts are well-structured, clearly written, and provide significant contributions to the field. All submissions will undergo rigorous peer review process to ensure the highest standards of scientific quality and integrity.

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Frontiers in Physiology

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