Acute Kidney Injury (AKI) is a common and severe complication observed in patients with neoplastic diseases. The pathophysiology of AKI in this population is complex and multifactorial, encompassing a range of mechanisms including tumour invasion, chemotherapy-induced nephrotoxicity, sepsis, and obstructive uropathy, among others. Despite advancements in cancer treatment significantly improving patient prognosis and survival, the occurrence of AKI presents a critical challenge with substantial morbidity and mortality implications.
This Research Topic aims to compile the latest research and reviews on the incidence, mechanisms, management, and outcomes of AKI in patients with neoplasia. We invite contributions that explore:
Etiology and Pathophysiology: Investigations into the underlying mechanisms of AKI in patients with various types of neoplasia, including solid tumours and hematologic malignancies. Studies on the interplay between cancer therapies (chemotherapy, immunotherapy, radiation) and kidney injury are particularly welcome.
Diagnosis and Biomarkers: Advances in early detection of AKI in cancer patients through novel biomarkers, imaging techniques, and risk assessment models. Contributions discussing the limitations and potential improvements in current diagnostic criteria are also encouraged.
Management Strategies: Research on preventative measures and therapeutic approaches to mitigate the risk of AKI in neoplastic patients. This includes optimizing hydration protocols, adjusting chemotherapeutic regimens, and employing nephroprotective agents.
Clinical Outcomes: Longitudinal studies examining the short-term and long-term renal outcomes in cancer patients who develop AKI. Discussions on how AKI influences cancer treatment plans, patient quality of life, and overall survival rates.
Case Studies and Reviews: Comprehensive reviews and insightful case studies providing an in-depth analysis of clinical experiences and lessons learned in managing AKI in the context of neoplasia.
Future Directions: Innovative research proposals and preliminary findings for novel therapeutics, preventive strategies, and personalized medicine approaches tailored to this unique patient population.
By assembling a robust collection of original research articles, reviews, and case reports, this Research Topic seeks to enhance our understanding of AKI in patients with neoplasia and foster the development of effective strategies to improve patient outcomes.
We invite researchers, clinicians, and experts in nephrology, oncology, and related fields to contribute their valuable insights and advancements. Together, we can push the frontier of knowledge in this critical intersection of nephrology and oncology.
Keywords:
Acute Kidney Injury (AKI), Nephrotoxicity, Chemotherapy, Sepsis, Cancer Treatment, AKI Mechanisms, Immunotherapy, Radiation, Kidney Injury, Biomarkers, Nephroprotective Agents, Renal Outcomes, Personalized Medicine
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
Acute Kidney Injury (AKI) is a common and severe complication observed in patients with neoplastic diseases. The pathophysiology of AKI in this population is complex and multifactorial, encompassing a range of mechanisms including tumour invasion, chemotherapy-induced nephrotoxicity, sepsis, and obstructive uropathy, among others. Despite advancements in cancer treatment significantly improving patient prognosis and survival, the occurrence of AKI presents a critical challenge with substantial morbidity and mortality implications.
This Research Topic aims to compile the latest research and reviews on the incidence, mechanisms, management, and outcomes of AKI in patients with neoplasia. We invite contributions that explore:
Etiology and Pathophysiology: Investigations into the underlying mechanisms of AKI in patients with various types of neoplasia, including solid tumours and hematologic malignancies. Studies on the interplay between cancer therapies (chemotherapy, immunotherapy, radiation) and kidney injury are particularly welcome.
Diagnosis and Biomarkers: Advances in early detection of AKI in cancer patients through novel biomarkers, imaging techniques, and risk assessment models. Contributions discussing the limitations and potential improvements in current diagnostic criteria are also encouraged.
Management Strategies: Research on preventative measures and therapeutic approaches to mitigate the risk of AKI in neoplastic patients. This includes optimizing hydration protocols, adjusting chemotherapeutic regimens, and employing nephroprotective agents.
Clinical Outcomes: Longitudinal studies examining the short-term and long-term renal outcomes in cancer patients who develop AKI. Discussions on how AKI influences cancer treatment plans, patient quality of life, and overall survival rates.
Case Studies and Reviews: Comprehensive reviews and insightful case studies providing an in-depth analysis of clinical experiences and lessons learned in managing AKI in the context of neoplasia.
Future Directions: Innovative research proposals and preliminary findings for novel therapeutics, preventive strategies, and personalized medicine approaches tailored to this unique patient population.
By assembling a robust collection of original research articles, reviews, and case reports, this Research Topic seeks to enhance our understanding of AKI in patients with neoplasia and foster the development of effective strategies to improve patient outcomes.
We invite researchers, clinicians, and experts in nephrology, oncology, and related fields to contribute their valuable insights and advancements. Together, we can push the frontier of knowledge in this critical intersection of nephrology and oncology.
Keywords:
Acute Kidney Injury (AKI), Nephrotoxicity, Chemotherapy, Sepsis, Cancer Treatment, AKI Mechanisms, Immunotherapy, Radiation, Kidney Injury, Biomarkers, Nephroprotective Agents, Renal Outcomes, Personalized Medicine
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.