In the relentless battle against microbial resistance, the quest for novel antimicrobials has become a paramount concern. The design and synthesis of natural antimicrobial derivatives stand at the forefront of this challenge, drawing inspiration from the wealth of compounds produced by nature itself. These derivatives not only offer a promising avenue for combating drug-resistant strains but also hold the potential for reduced side effects and ecological impact compared to conventional antibiotics. Recent advancements in synthetic biology, nanotechnology, and computational chemistry have opened new pathways for the development of these bio-inspired agents, making it a ripe area of research with the promise of groundbreaking discoveries.

The primary objective of this Research Topic is to explore innovative approaches to the design and synthesis of natural antimicrobial derivatives that can address the growing issue of antibiotic resistance. We aim to showcase research that pushes the boundaries of current methodologies, incorporating recent advancements in chemistry, biotechnology, and materials science. Contributions may include but are not limited to, studies on novel biosynthetic pathways, optimization of antimicrobial peptides, development of bioactive nanocomposites, and computational models for predicting antimicrobial activity. By bringing together cutting-edge research, this special issue seeks to foster a multidisciplinary dialogue and catalyze the development of effective, sustainable antimicrobial agents.

We welcome original research articles, reviews, and brief communications that contribute to the understanding of antimicrobial resistance mechanisms, novel antimicrobial agent synthesis, and their applications. Through this Research Topic, we aim to highlight innovative strategies that can lead to the development of next-generation antimicrobials. This Research Topic invites contributions on the design and synthesis of natural antimicrobial derivatives, encompassing a wide array of research areas. Specific topics of interest include, but are not limited to:

1. Biosynthesis of novel antimicrobial compounds.

2. Optimization and functionalization of antimicrobial peptides.

3. Development of antimicrobial nanomaterials.

4. Computational approaches for the design of bioactive molecules.

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Frontiers in Pharmacology

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