About this Research Topic
The retina is a highly metabolically active tissue in our body. Therefore, its functions should be highly supported by nutrients as well as oxygen. Imbalance of their delivery via blood vessels leads to retinal dysfunction, resulting in visual impairment. Retinal ischemia occurs in occlusions of retinal and ophthalmic veins or arteries, ageing, or in systemic metabolic disorders. Many people suffer from visual impairment and blindness induced by retinal ischemia. Preclinical studies have been searching for, or developing promising neuroprotective drugs against vision loss induced by retinal ischemic stress.
Anti-VEGF antibodies are widely used to treat ischemic retinal diseases. However, these strategies are not effective against retinal neuronal degenerative process. Novel therapies including bio-active compounds from diet or tissue-specific genetic modulation are highly desirable to maintain neuroprotective effects against ischemic retinal degeneration.
This research topic will focus on understanding of metabolic or oxidative damage that occur during retinal degenerative processes in the outer or inner retina, and potential neuroprotective molecular targets, including genetics or pharmacology mechanisms. This collection welcomes original research as well as review articles targeting ischemic retinopathy: diabetic retinopathy, glaucoma, severe myopia, and age-related macular degeneration. Furthermore, new diagnostic techniques to study metabolic dynamics in the ischemic retina are also welcome.
Anti-VEGF antibodies are widely used to treat ischemic retinal diseases. However, these strategies are not effective against retinal neuronal degenerative process. Novel therapies including bio-active compounds from diet or tissue-specific genetic modulation are highly desirable to maintain neuroprotective effects against ischemic retinal degeneration.
This research topic will focus on understanding of metabolic or oxidative damage that occur during retinal degenerative processes in the outer or inner retina, and potential neuroprotective molecular targets, including genetics or pharmacology mechanisms. This collection welcomes original research as well as review articles targeting ischemic retinopathy: diabetic retinopathy, glaucoma, severe myopia, and age-related macular degeneration. Furthermore, new diagnostic techniques to study metabolic dynamics in the ischemic retina are also welcome.
Keywords: Ischemia, Hypoxia, Neuroprotection, Angiogenesis, Diabetic retinopathy, Glaucoma, Age-related macular degeneration
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
