Allergies are heterogeneous diseases characterised by hypersensitivity reactions to harmless antigens, mainly drugs, environmental or food allergens, which affect more than 25% of the population in industrialized countries, with important implications for human health and representing a significant burden on healthcare systems. Although significant advances have been made in recent decades, important gaps remain poorly understood, mainly related to the diagnosis, treatment, and management of allergic patients. Deepening the knowledge of the specific mechanism involved in each allergic reaction is essential to better determine the specific endotype of each reaction, important for the identification of specific biomarkers, as well as to find out potential therapeutic targets. The rise of –omic sciences in biomedicine opens a wide range of possibilities in the field of personalized medicine. Nevertheless, despite important advances, further research is needed to translate basic research into clinical practice in the allergy field.

This research topic will focus on the main important and relevant contributions of -omic sciences, mainly proteomic, metabolomic, genomic/epigenomic and transcriptomic in the field of allergy. These novel techniques allow deepening the understanding of the mechanisms involved in these reactions. The data obtained from this research topic will be useful both from clinical and basic immunology perspectives, with the main idea of translate this information to clinical practice. Due to the important increase in the -omic sciences during the last decades, this information will be of special relevance for the allergy field but also for knowledge in immunology in general. This research topic will cover the most relevant advances in the field of allergic diseases from a broad perspective, delving into the uniqueness of each type of reaction.

The proposed research topic will cover different aspects of allergic diseases, so it is expected to have an important impact both in allergy and in the basic and translational clinical immunology field. The data obtained here will help to better understand the immunological processes involved in these reactions, to identify or standardise specific biomarkers, as well as to describe new potential therapeutic targets. This research topic is expected to have a major impact on the field, with important implications for clinicians, patients, and healthcare systems. This Research Topic welcomes submissions of Original Research Articles, Clinical Case Reports, Reviews and Mini-Reviews on novel studies performed in the diagnosis, treatment and novel mechanisms of allergic diseases based on omics techniques. The specific subject areas of interest include but are not limited to:

- Use of omic sciences in the study of allergic diseases.
- Biomarkers in drug, food and respiratory allergic diseases.
- New insights in the mechanisms involved in allergic diseases.
- Revealing potential therapeutic targets in allergic diseases.
- Innovative diagnostic tools for allergic reactions.
- New experimental models that address the complexity of these diseases.

The Research Topic editors confirm that they have no conflicts of interest to declare in relation to the editorship of this collection.

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Frontiers in Immunology

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