About this Research Topic
The ubiquitous presence of plasticizers in everyday products has raised concerns regarding their potential impact on human health and disease. Some plasticizers, such as bisphenols and phthalates, with recognized endocrine-disrupting activity, are widely used in producing plastics, food packaging, thermal paper, and various consumer goods.
This Research Topic aims to investigate the intricate effects of plasticizers on human health and disease. Specifically, we seek to explore their mechanisms of action, toxicokinetics, and potential contributions to various health conditions, including but not limited to reproductive disorders, metabolic syndrome, cancer, neurodevelopmental disorders, and cardiovascular diseases. Furthermore, recent studies have highlighted the role of the gut microbiota in processing xenobiotics. The gut microbiota's response to plasticizer exposure may exacerbate certain pathological conditions, adding another layer of complexity to their impact on human health.
This Research Topic provides a dedicated platform for researchers, clinicians, and policymakers to share their latest findings on the chronic toxic effects of various plasticizers, their impact on populations, and the integration of the gut microbiota into this complex relationship. Contributions from diverse fields such as toxicology, environmental science, chemistry, and computer science are encouraged to offer perspectives, novel approaches, and advanced research on the toxicology of plasticizers. Through collaborative efforts, this research endeavor aims to enhance our understanding of the effects of plasticizers, facilitate informed decision-making, establish protective strategies, and ensure the preservation of ecosystems and human health in the face of plasticizers exposure. Ultimately, this research will contribute to developing evidence-based guidelines for safer plasticizer use and environmental management.
We welcome Original Research, Methods, Reviews and Study Protocols to this Research Topic which cover themes including but not limited to:
• Investigation into the role of gut microbiota in mediating the toxic effects of plasticizers, exploring potential interactions and pathways.
• Assessment of plasticizer exposure on the overall and in vulnerable populations, such as infants and pregnant women, shedding light on potential health risks, including but not limited to neurotoxic, oxidative stress, inflammation, and epigenetic effects.
• Study of the interactions of plasticizers with other environmental contaminants (e.g. metals), to understand synergistic effects on human health.
• Development of novel biomarkers for assessing plasticizer exposure and its associated health outcomes, advancing diagnostic and preventive strategies.
This Research Topic aims to investigate the intricate effects of plasticizers on human health and disease. Specifically, we seek to explore their mechanisms of action, toxicokinetics, and potential contributions to various health conditions, including but not limited to reproductive disorders, metabolic syndrome, cancer, neurodevelopmental disorders, and cardiovascular diseases. Furthermore, recent studies have highlighted the role of the gut microbiota in processing xenobiotics. The gut microbiota's response to plasticizer exposure may exacerbate certain pathological conditions, adding another layer of complexity to their impact on human health.
This Research Topic provides a dedicated platform for researchers, clinicians, and policymakers to share their latest findings on the chronic toxic effects of various plasticizers, their impact on populations, and the integration of the gut microbiota into this complex relationship. Contributions from diverse fields such as toxicology, environmental science, chemistry, and computer science are encouraged to offer perspectives, novel approaches, and advanced research on the toxicology of plasticizers. Through collaborative efforts, this research endeavor aims to enhance our understanding of the effects of plasticizers, facilitate informed decision-making, establish protective strategies, and ensure the preservation of ecosystems and human health in the face of plasticizers exposure. Ultimately, this research will contribute to developing evidence-based guidelines for safer plasticizer use and environmental management.
We welcome Original Research, Methods, Reviews and Study Protocols to this Research Topic which cover themes including but not limited to:
• Investigation into the role of gut microbiota in mediating the toxic effects of plasticizers, exploring potential interactions and pathways.
• Assessment of plasticizer exposure on the overall and in vulnerable populations, such as infants and pregnant women, shedding light on potential health risks, including but not limited to neurotoxic, oxidative stress, inflammation, and epigenetic effects.
• Study of the interactions of plasticizers with other environmental contaminants (e.g. metals), to understand synergistic effects on human health.
• Development of novel biomarkers for assessing plasticizer exposure and its associated health outcomes, advancing diagnostic and preventive strategies.
Keywords: Plasticizers, Gut Microbiota, Human Health, new approach methodologies (NAMs), risk assessment, endocrine disruptors, emerging contaminants
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
