Biofilm formation by microorganisms represents a formidable hurdle in medical treatment due to their complex, structured communities encased in a self-generated extracellular matrix. This matrix enhances their defense mechanisms, making them highly resistant to standard antimicrobial therapies and contributing to persistent infections and treatment challenges. Addressing biofilm-related complications is therefore critical for improving clinical outcomes.

This research theme focuses on pioneering the discovery and advancement of new antibiofilm and antimicrobial methodologies. Emphasizing novel chemical entities, biotherapeutic agents, and cutting-edge combination therapies, this research aims to uncover potent strategies for inhibiting biofilm formation and disrupting established biofilms. Key areas of interest include elucidating mechanisms of action, evaluating efficacy across various models, and assessing potential clinical applications to fortify our arsenal against biofilm-driven infections.

Researchers are invited to contribute to this theme by delving into topics such as:

o Development of new chemical structures with antibiofilm activity

o Biotherapeutic interventions targeting biofilm development

o Combined therapeutic approaches for superior antibiofilm effectiveness

o Investigating the mechanisms underlying antibiofilm and antimicrobial actions

o Assessing the effectiveness of novel inhibitors in both laboratory and clinical models

o Translational research that bridges laboratory findings with clinical practice

o Identifying challenges and opportunities in antibiofilm agent development

This research initiative encourages comprehensive exploration into these areas, aiming to foster collaborative efforts and synergy among scientists. By doing so, it seeks to drive forward advancements in the prevention and eradication of biofilm-associated infections, enhancing therapeutic success in medical practice.

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Frontiers in Cellular and Infection Microbiology

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