Histone lysine lactylation (Kla) was first identified as a novel post-translational modification (PTM) in 2019 by Zhao et al. Recently, an increasing number of studies have revealed that lactylation is widely observed in histone and non-histone proteins and plays critical roles in the progression of many diseases, such as cancer, kidney injury, cardiovascular disease, liver fibrosis, etc. However, the detailed roles and regulatory mechanisms underlying protein lactylation in disease progression are still largely unclear.
The goal of this research topic is to provide a comprehensive overview of the detailed roles and regulatory mechanisms of protein lactylation in disease progression, including the identification of histone lactylation-activated genes and the unraveling of the underlying mechanisms, identification of non-histone proteins that are lactylated in disease progression, and the new factors that regulate protein lactylation.
We welcome discussions covering, but not limited to, the following aspects:
1. Biological function of protein lactylation in disease progression.
2. Protein lactylation as a target for disease therapy.
3. New lactyltransferases in disease progression.
4. New delactylation enzymes in disease progression.
5. Other mechanisms that regulate protein lactylation in disease progression.
Keywords:
Lactylation, histone, nonhistone protein, disease, therapeutic targets
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
Histone lysine lactylation (Kla) was first identified as a novel post-translational modification (PTM) in 2019 by Zhao et al. Recently, an increasing number of studies have revealed that lactylation is widely observed in histone and non-histone proteins and plays critical roles in the progression of many diseases, such as cancer, kidney injury, cardiovascular disease, liver fibrosis, etc. However, the detailed roles and regulatory mechanisms underlying protein lactylation in disease progression are still largely unclear.
The goal of this research topic is to provide a comprehensive overview of the detailed roles and regulatory mechanisms of protein lactylation in disease progression, including the identification of histone lactylation-activated genes and the unraveling of the underlying mechanisms, identification of non-histone proteins that are lactylated in disease progression, and the new factors that regulate protein lactylation.
We welcome discussions covering, but not limited to, the following aspects:
1. Biological function of protein lactylation in disease progression.
2. Protein lactylation as a target for disease therapy.
3. New lactyltransferases in disease progression.
4. New delactylation enzymes in disease progression.
5. Other mechanisms that regulate protein lactylation in disease progression.
Keywords:
Lactylation, histone, nonhistone protein, disease, therapeutic targets
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.