The microenvironmental evolution of chronic diseases and tumors in the digestive tract is a burgeoning field of research that holds significant promise for advancing our understanding of disease mechanisms and improving patient outcomes. The digestive tract, a critical component of the human body, is not only essential for digestion and nutrient absorption but also plays a pivotal role in immune system function. However, it is vulnerable to a range of chronic diseases and malignancies, such as inflammatory bowel diseases, colorectal cancer, gastric cancer, and pancreatic cancer. The microenvironment within the digestive tract is a complex interplay of epithelial cells, immune cells, stromal components, and microbiota, all of which influence disease onset, progression, and treatment response. Recent studies have highlighted the role of chronic inflammation and microbiota dysbiosis in tumorigenesis, as well as the mechanisms of immune evasion within the tumor microenvironment. Despite these advances, there remains a critical need for further investigation into how these microenvironmental factors can be harnessed to develop new diagnostic and therapeutic strategies.

This Research Topic aims to compile and showcase the latest research findings on the microenvironmental changes in the digestive tract and their impact on disease progression. The primary objective is to explore how these microenvironmental characteristics can be leveraged to identify new diagnostic markers and therapeutic targets. Key questions include understanding the composition and function of the microbiome, the interactions between immune cells and tumor cells, the role of chronic inflammation, and the function of stromal components within the tumor microenvironment. By addressing these questions, the research aims to drive innovation in early diagnosis, prevention, and treatment of digestive tract diseases, ultimately improving patient outcomes and quality of life.

To gather further insights into the microenvironmental evolution of chronic diseases and tumors in the digestive tract, we welcome articles addressing, but not limited to, the following themes:
- Composition and Role of the Microenvironment in Disease: Investigating the roles of immune cells, epithelial cells, stromal components, and microbiota.
- Chronic Inflammation and Disease Progression: Exploring mechanisms of chronic inflammation and its influence on tumor formation.
- Immune Evasion Mechanisms in the Tumor Microenvironment: Understanding how tumors evade host immune surveillance.
- Interactions Between Stromal Components and the Tumor Microenvironment: Examining the influence of stromal components on tumor growth.
- Impact of the Microenvironment on Treatment Response: Analyzing how microenvironmental factors affect treatment efficacy.
- Development of New Diagnostic Markers and Therapeutic Targets: Identifying and validating new molecular and cellular markers.
- Translational Research: Addressing pathways and challenges in applying basic research findings to clinical practice.
- Molecular and Cellular Mechanisms of Microenvironmental Changes: Conducting basic research on the molecular and cellular basis of microenvironmental changes.

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Frontiers in Molecular Biosciences

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