Cholangiocarcinoma, a malignancy of the bile ducts, is an area of growing concern within the field of oncology due to its increasing incidence and high mortality rate. Despite advancements in medical science, the disease remains challenging to diagnose and treat effectively, with limited therapeutic options available. Current diagnostic practices primarily rely on histopathological assessments, which, while standard, may not always provide the precision needed for early detection and effective management. Recent studies have highlighted advancements in diagnostic procedures, including imaging techniques and biomarker identification, which offer promise for more accurate detection. However, there remains a significant gap in integrating these innovations into routine clinical practice, necessitating further research to refine these methods and explore new therapeutic strategies.

This research topic aims to identify and evaluate the most effective diagnostic approaches for cholangiocarcinoma, focusing on enhancing precision and efficacy. Additionally, it seeks to provide a comprehensive overview of the latest therapeutic advancements and management strategies, with an emphasis on innovative treatment modalities and the benefits of a multidisciplinary approach. By addressing these objectives, the research aims to contribute to improved patient outcomes and a deeper understanding of this complex disease.

To gather further insights into the diagnosis and therapy of cholangiocarcinoma, we welcome articles addressing, but not limited to, the following themes:
- Recent advancements and emerging developments in the diagnosis and therapy of cholangiocarcinoma
- Insights into the evolving landscape of this challenging disease
- Surgical intervention strategies
- Targeted therapy as monotherapy or in combination with chemo- and/or immunotherapy

Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases, which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo), are out of scope for this section and will not be accepted as part of this Research Topic.

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Frontiers in Oncology

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