RNA Regulation Mechanisms in Microbial-Host Interactions

The field of RNA regulation mechanisms in microbial-host interactions is a rapidly evolving area of research that delves into the complex dynamics between pathogens and their host organisms. RNA molecules, such as mRNA, miRNA, lncRNA, and circular RNA, are not merely intermediaries in gene expression but serve as crucial modulators of cellular responses during infections. Recent studies have highlighted the diverse strategies employed by both microbes and hosts to manipulate RNA molecules, either to facilitate infection or to bolster immune defenses. For example, RNA methylation and expression levels have been identified as key regulatory mechanisms at the host-pathogen interface, influencing the stability and translation of critical mRNAs and noncoding RNAs. Viral pathogens often exploit host RNA machinery for genome replication and protein production, disrupting normal cellular functions. Additionally, some viruses use RNA-binding proteins and microRNAs to alter host gene expression, enhancing their survival and pathogenicity. Bacteria also utilize RNA regulators, such as small RNAs (sRNAs), to adjust their gene expression in response to host environments. Despite these advances, the precise roles of RNA molecules and their modifications in modulating host immune responses and microbial strategies remain incompletely understood, necessitating further investigation.

This research topic aims to elucidate the RNA regulation mechanisms that govern microbial-host interactions. By fostering research into the mechanistic aspects of RNA modifications, RNA expression, and their regulatory networks, this topic seeks to bridge existing knowledge gaps. The ultimate goal is to uncover how RNA-based mechanisms can be exploited by pathogens to evade immune detection and how they can be harnessed by hosts to mount effective defenses. This research endeavor aspires to identify novel RNA-centric therapeutic targets and strategies to combat infectious diseases, thereby enhancing our ability to address current and emerging public health threats.

To gather further insights into the intricate dynamics of RNA regulation in microbial-host interactions, we welcome articles addressing, but not limited to, the following themes:
- Mechanisms by which viruses hijack host RNA machinery to enhance replication and evade immune responses.
- The role of small RNAs (sRNAs) and other RNA molecules in bacterial pathogenesis and adaptation to host environments.
- Host cellular responses and RNA-based defenses against microbial infections.
- Development of RNA-targeted therapies to combat microbial infections and restore host health.
- Innovative techniques for studying RNA regulation in microbial-host interactions, including RNA-seq or RNA expression mechanisms.