The intricate interplay between microbial pathogens and host organisms is governed by a myriad of regulatory mechanisms, with RNA regulation plays a pivotal role. RNA molecules, including mRNA, miRNA, lncRNA, and circular RNA, are not mere intermediaries in gene expression but also are crucial modulators of cellular responses to infection. Recent studies have illuminated the diverse strategies employed by both microbes and hosts to leverage RNA molecules, either to promote infection or to mount an effective immune response. For instance, the modulation of RNA methylation and RNA expression level has been identified as a key regulatory mechanism in the host-pathogen interface. It influences the stability and translation of some mRNAs and noncoding RNA that are critical for immune responses and pathogen survival. Viral pathogens often hijack host RNA machinery for genome replication and viral protein production, thereby disrupting normal cellular functions. Furthermore, some viruses employ RNA-binding proteins and microRNAs to manipulate host gene expression, enhancing their survival and pathogenicity. Some bacteria also utilize RNA regulators, such as small RNAs (sRNAs) to modulate their own gene expression in response to host environments.
This Research Topic is focused on elucidating the RNA regulation mechanisms that govern microbial-host interactions. Despite significant advances, the precise roles of RNA molecules and their modifications in modulating host immune responses and microbial strategies remain incompletely understood. By fostering research into the mechanistic aspects of RNA modifications, RNA expression, and their regulatory networks, this topic aims to bridge existing knowledge gaps. We seek to uncover how these RNA-based mechanisms can be exploited by pathogens to evade immune detection and how they can be harnessed by hosts to mount effective defenses. Ultimately, this Research Topic aspires to identify novel RNA-centric therapeutic targets and strategies to combat infectious diseases, thereby enhancing our ability to address current and emerging public health threats.
Authors are encouraged to submit original research, reviews, and perspectives that provide new insights into RNA regulation mechanisms in different microbial-host interactions. We invite contributors to address the following specific themes:
- Mechanisms by which viruses hijack host RNA machinery to enhance replication and evade immune responses.
- The role of small RNAs (sRNAs) and other RNA molecules in bacterial pathogenesis and adaptation to host environments.
- Host cellular responses and RNA-based defenses against microbial infections.
- Development of RNA-targeted therapies to combat microbial infections and restore host health.
- Innovative techniques for studying RNA regulation in microbial-host interactions, including RNA-seq or RNA expression mechanism.
Keywords:
Microbes, Virus, Bioinformatics, RNA, Bacteria
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
The intricate interplay between microbial pathogens and host organisms is governed by a myriad of regulatory mechanisms, with RNA regulation plays a pivotal role. RNA molecules, including mRNA, miRNA, lncRNA, and circular RNA, are not mere intermediaries in gene expression but also are crucial modulators of cellular responses to infection. Recent studies have illuminated the diverse strategies employed by both microbes and hosts to leverage RNA molecules, either to promote infection or to mount an effective immune response. For instance, the modulation of RNA methylation and RNA expression level has been identified as a key regulatory mechanism in the host-pathogen interface. It influences the stability and translation of some mRNAs and noncoding RNA that are critical for immune responses and pathogen survival. Viral pathogens often hijack host RNA machinery for genome replication and viral protein production, thereby disrupting normal cellular functions. Furthermore, some viruses employ RNA-binding proteins and microRNAs to manipulate host gene expression, enhancing their survival and pathogenicity. Some bacteria also utilize RNA regulators, such as small RNAs (sRNAs) to modulate their own gene expression in response to host environments.
This Research Topic is focused on elucidating the RNA regulation mechanisms that govern microbial-host interactions. Despite significant advances, the precise roles of RNA molecules and their modifications in modulating host immune responses and microbial strategies remain incompletely understood. By fostering research into the mechanistic aspects of RNA modifications, RNA expression, and their regulatory networks, this topic aims to bridge existing knowledge gaps. We seek to uncover how these RNA-based mechanisms can be exploited by pathogens to evade immune detection and how they can be harnessed by hosts to mount effective defenses. Ultimately, this Research Topic aspires to identify novel RNA-centric therapeutic targets and strategies to combat infectious diseases, thereby enhancing our ability to address current and emerging public health threats.
Authors are encouraged to submit original research, reviews, and perspectives that provide new insights into RNA regulation mechanisms in different microbial-host interactions. We invite contributors to address the following specific themes:
- Mechanisms by which viruses hijack host RNA machinery to enhance replication and evade immune responses.
- The role of small RNAs (sRNAs) and other RNA molecules in bacterial pathogenesis and adaptation to host environments.
- Host cellular responses and RNA-based defenses against microbial infections.
- Development of RNA-targeted therapies to combat microbial infections and restore host health.
- Innovative techniques for studying RNA regulation in microbial-host interactions, including RNA-seq or RNA expression mechanism.
Keywords:
Microbes, Virus, Bioinformatics, RNA, Bacteria
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.