About this Research Topic
Innate immunity represents an important arm of immune response, vital to sensing damages, pathogenic or non-pathogenic, and to repair the injury tissue. It comprehends several elements including receptors, molecules, tissues and cells. New cells have been identified in recent years, such as MAIT and ILCs, and new function for ‘old’ cells, such as NKT and NK cells. Recent data have also suggested that innate immune cells might present memory. Due to its strategical location, innate immune cells are associated with protection from mucosa, composition of local microbiota, and tissue homeostasis. Chronic non transmissible diseases are epidemic worldwide and represent a category of inflammatory diseases where innate immunity might play a fundamental role, from development to tissue architectural alterations, in late phases.
We expect to have outstanding articles, original and review, emphasizing the role of all components of innate immunity, specially immune cells, in experimental model of chronic non-transmissible diseases and in human samples. We hope to stimulate work that combine immunology with biochemical, physiology and pharmacological fields to uncover new function for innate immunity in diseases. The issue can be broader to include data from in silico analyses and other non-rodent models where innate immunity plays a role.
This Research Topic accepts Brief Research Report, Case Report, Classification, Clinical Trial, Correction, General Commentary, Hypothesis & Theory, Methods, Mini Review, Opinion, Original Research, Perspective, Review, Study Protocol, Systematic Review, Technology and Code. We welcome manuscripts focusing on, but not limited to, the following sub-topics:
• Advances in sensing by innate receptors: far beyond pathogen recognition
• Signaling pathways in sensing by innate receptors
• Uncovering the tissue specific resident cells
• New role of new and old innate cells: (re)discovering MAIT, NKT, ILCs and NK cells
• Immunometabolism and innate immunity
• Tissue fibrosis and innate immunity
• Memory in innate immunity
Please note: Manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by robust and relevant validation, for instance in an independent patient population or by PCR, are considered out of scope of this section.
Topic Editor Renato Monteiro received grants from Moderna, Shire and Biomarin. He is a co-founder of Inatherys. The other Topic Editors declare no competing interests with regard to the Research Topic subject.
We expect to have outstanding articles, original and review, emphasizing the role of all components of innate immunity, specially immune cells, in experimental model of chronic non-transmissible diseases and in human samples. We hope to stimulate work that combine immunology with biochemical, physiology and pharmacological fields to uncover new function for innate immunity in diseases. The issue can be broader to include data from in silico analyses and other non-rodent models where innate immunity plays a role.
This Research Topic accepts Brief Research Report, Case Report, Classification, Clinical Trial, Correction, General Commentary, Hypothesis & Theory, Methods, Mini Review, Opinion, Original Research, Perspective, Review, Study Protocol, Systematic Review, Technology and Code. We welcome manuscripts focusing on, but not limited to, the following sub-topics:
• Advances in sensing by innate receptors: far beyond pathogen recognition
• Signaling pathways in sensing by innate receptors
• Uncovering the tissue specific resident cells
• New role of new and old innate cells: (re)discovering MAIT, NKT, ILCs and NK cells
• Immunometabolism and innate immunity
• Tissue fibrosis and innate immunity
• Memory in innate immunity
Please note: Manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by robust and relevant validation, for instance in an independent patient population or by PCR, are considered out of scope of this section.
Topic Editor Renato Monteiro received grants from Moderna, Shire and Biomarin. He is a co-founder of Inatherys. The other Topic Editors declare no competing interests with regard to the Research Topic subject.
Keywords: Innate immunity, innate cells, sensing, training immunity, MAIT cells, NKT cells
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
