As the global population ages, age-related health issues have become a significant concern worldwide. This includes a range of diseases associated with endocrine metabolic disorders, sleep disorders, and shortened and abnormal telomeres. These health problems have a profound impact on individual quality of life and pose substantial burdens on healthcare systems and socio-economic factors. Therefore, investigating the mechanisms underlying age-related endocrine metabolic disorders, sleep disorders, and diseases associated with shortened and abnormal telomeres is crucial. It provides insights into the development and progression of these health issues, offering a scientific basis for prevention, diagnosis, and treatment. Ultimately, this research contributes to improving the health status of the elderly population.

To address these problems, it is crucial to conduct in-depth research into their underlying mechanisms and find appropriate prevention, diagnosis, and treatment methods.

Firstly, in age-related endocrine metabolic disorders, researchers have identified various molecular mechanisms related to the aging process and metabolic abnormalities, such as insulin resistance and inflammatory responses. These findings provide a foundation for the development of new drugs and treatment strategies.

Secondly, in the field of sleep disorders, scientists have gained a deeper understanding of the regulatory mechanisms of sleep. Factors such as neurotransmitters, temperature regulation, and biological clocks play important roles in the occurrence and development of sleep disorders. This research supports the design of interventions to improve sleep quality.

Lastly, in diseases associated with shortened and abnormal telomeres, researchers have discovered key molecules that affect telomere stability and repair mechanisms. These findings offer new insights into developing therapeutic approaches targeting telomere protection and extension.

The scope of the Research Topic encompasses the mechanisms underlying age-related endocrine metabolic disorders, sleep disorders, and diseases associated with shortened and abnormal telomeres. We invite contributors to address various aspects of these topics, including but not limited to the following themes:

1. Molecular and cellular mechanisms: Manuscripts focusing on the molecular and cellular processes involved in the development and progression of age-related endocrine metabolic disorders, sleep disorders, and diseases associated with shortened and abnormal telomeres.
2. Pathophysiology and disease progression: Submissions exploring the pathophysiological changes associated with these conditions, including disruptions in hormone regulation, telomere dysfunction, sleep-wake cycle abnormalities.
3. Diagnostic approaches: Articles discussing novel diagnostic techniques and biomarkers for early detection and accurate diagnosis of age-related endocrine metabolic disorders, sleep disorders, and diseases associated with shortened and abnormal telomeres.
4. Therapeutic interventions: Manuscripts presenting innovative therapeutic strategies, including pharmacological approaches, lifestyle interventions, and targeted therapies, aimed at managing and treating these health conditions effectively.

We encourage original research articles, reviews, mini-reviews, clinical studies, and perspective articles that contribute to a comprehensive understanding of the underlying mechanisms and advancements in the prevention, diagnosis, and treatment of age-related endocrine metabolic disorders, sleep disorders, and diseases associated with shortened and abnormal telomeres.

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Frontiers in Aging

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