Colorectal Cancer (CRC) is known as one of the most frequent malignancies worldwide. Despite it being more common in people over 50 years of age, its incidence has been decreasing over the last decade. Nonetheless, cases among younger patients have been rising, and this phenomenon is prompted to double ciphers by 2030. Early-onset colorectal cancer (EO-CRC) is related to several risk factors such as Lynch syndrome, inflammatory bowel disease, inherited cancer, sedentarism, and obesity. CRC is categorized into the consensus molecular subtypes (CMS), yet EO-CRC is likely to present CMS1 or CMS2. CMS1 exhibits microsatellite instability, JAK-STAT activation, and hypermutated DNA, while CMS2 is related to canonical Wnt/MYC. Despite this acknowledgment, molecular mechanisms and epigenetic changes accompanying EO-CRC carcinogenesis are still limited, comprehending pivotal characteristics that could aid in finding new therapeutic strategies.
To comprehensively investigate the molecular pathways and epigenetic mechanisms underlying early-onset colorectal cancer (EO-CRC), with the aim of elucidating key drivers and identifying potential therapeutic targets regarding diagnosis, treatments, and follow-up. This Research Topic calls for investigations to integrate cutting-edge molecular biology techniques and epigenetic analyses to unravel the complexities of EO-CRC carcinogenesis, ultimately contributing to the development of novel diagnostic tools and targeted therapeutic strategies for this subset of patients as well as impacting the rising number of cases.
To comprehensively investigate the molecular pathways and epigenetic mechanisms underlying early-onset colorectal cancer (EO-CRC), with the aim of elucidating key drivers and identifying potential therapeutic targets regarding diagnosis, treatments, and follow-up. This Research Topic calls for investigations to integrate cutting-edge molecular biology techniques and epigenetic analyses to unravel the complexities of EO-CRC carcinogenesis, ultimately contributing to the development of novel diagnostic tools and targeted therapeutic strategies for this subset of patients as well as impacting the rising number of cases.
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
Keywords:
colorectal cancer, early-onset, epigenetics, molecular pathways, carcinogenesis
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
Colorectal Cancer (CRC) is known as one of the most frequent malignancies worldwide. Despite it being more common in people over 50 years of age, its incidence has been decreasing over the last decade. Nonetheless, cases among younger patients have been rising, and this phenomenon is prompted to double ciphers by 2030. Early-onset colorectal cancer (EO-CRC) is related to several risk factors such as Lynch syndrome, inflammatory bowel disease, inherited cancer, sedentarism, and obesity. CRC is categorized into the consensus molecular subtypes (CMS), yet EO-CRC is likely to present CMS1 or CMS2. CMS1 exhibits microsatellite instability, JAK-STAT activation, and hypermutated DNA, while CMS2 is related to canonical Wnt/MYC. Despite this acknowledgment, molecular mechanisms and epigenetic changes accompanying EO-CRC carcinogenesis are still limited, comprehending pivotal characteristics that could aid in finding new therapeutic strategies.
To comprehensively investigate the molecular pathways and epigenetic mechanisms underlying early-onset colorectal cancer (EO-CRC), with the aim of elucidating key drivers and identifying potential therapeutic targets regarding diagnosis, treatments, and follow-up. This Research Topic calls for investigations to integrate cutting-edge molecular biology techniques and epigenetic analyses to unravel the complexities of EO-CRC carcinogenesis, ultimately contributing to the development of novel diagnostic tools and targeted therapeutic strategies for this subset of patients as well as impacting the rising number of cases.
To comprehensively investigate the molecular pathways and epigenetic mechanisms underlying early-onset colorectal cancer (EO-CRC), with the aim of elucidating key drivers and identifying potential therapeutic targets regarding diagnosis, treatments, and follow-up. This Research Topic calls for investigations to integrate cutting-edge molecular biology techniques and epigenetic analyses to unravel the complexities of EO-CRC carcinogenesis, ultimately contributing to the development of novel diagnostic tools and targeted therapeutic strategies for this subset of patients as well as impacting the rising number of cases.
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
Keywords:
colorectal cancer, early-onset, epigenetics, molecular pathways, carcinogenesis
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.