Glucose metabolic disorders are closely linked to various diseases, including tumors and inflammatory conditions, which involve significant metabolic abnormalities. By using epigenomics and epigenetics techniques, changes in disease-associated chromatin markers are investigated to understand their impact on gene expression, disease progression, and development. Histone lactylation, a recently discovered epigenetic modification, has been reported to directly regulate gene transcription from chromatin. However, its specific roles in various diseases remain largely unexplored. Thus, investigating the epigenetic modification mechanisms in glycolysis and OXPHOS-mediated diseases is essential.
The research topic aims to publish innovative research from observational, clinical, and basic science studies on the role of glucose metabolism in mediating epigenomic alterations in tumors and inflammatory diseases. We seek research utilizing advanced technologies such as single-cell sequencing, ChIP-seq, and CUT&Tag.
We are particularly interested in papers addressing the following areas:
• New studies confront existing concepts and hypotheses regarding the pathological basis of adult health and glucose metabolism-mediated disease;
• Identification of new pathways or mechanisms by which histone lactylation modifications influence the risk of inflammatory diseases and tumors;
• Interventions or new drug research targeting key catalytic enzymes and targets in metabolic diseases;
• Research of the auxiliary treatment and of its safety of metabolic diseases based on the application of nano-engineering medicine, organoids, artificial intelligence and other new technologies.
Keywords:
glucose metabolism, histone lactylation, epigenetic modifications, tumors and inflammatory diseases, advanced sequencing technologies
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
Glucose metabolic disorders are closely linked to various diseases, including tumors and inflammatory conditions, which involve significant metabolic abnormalities. By using epigenomics and epigenetics techniques, changes in disease-associated chromatin markers are investigated to understand their impact on gene expression, disease progression, and development. Histone lactylation, a recently discovered epigenetic modification, has been reported to directly regulate gene transcription from chromatin. However, its specific roles in various diseases remain largely unexplored. Thus, investigating the epigenetic modification mechanisms in glycolysis and OXPHOS-mediated diseases is essential.
The research topic aims to publish innovative research from observational, clinical, and basic science studies on the role of glucose metabolism in mediating epigenomic alterations in tumors and inflammatory diseases. We seek research utilizing advanced technologies such as single-cell sequencing, ChIP-seq, and CUT&Tag.
We are particularly interested in papers addressing the following areas:
• New studies confront existing concepts and hypotheses regarding the pathological basis of adult health and glucose metabolism-mediated disease;
• Identification of new pathways or mechanisms by which histone lactylation modifications influence the risk of inflammatory diseases and tumors;
• Interventions or new drug research targeting key catalytic enzymes and targets in metabolic diseases;
• Research of the auxiliary treatment and of its safety of metabolic diseases based on the application of nano-engineering medicine, organoids, artificial intelligence and other new technologies.
Keywords:
glucose metabolism, histone lactylation, epigenetic modifications, tumors and inflammatory diseases, advanced sequencing technologies
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.