About this Research Topic
Post-operative neurocognitive disorder (PND) is a prevalent complication following general anesthesia, particularly affecting older adults and those undergoing major surgeries. Characterized by deficits in memory, attention, and executive function, PND poses significant challenges to postoperative recovery. Concurrently, sleep disturbances, including insomnia, fragmented sleep, and altered sleep architecture, are frequently observed after surgery and can detrimentally impact both immediate recovery and long-term patient outcomes. Recent clinical studies have highlighted a notable correlation between postoperative sleep disturbances and the onset of PND, suggesting that disruptions in sleep may play a critical role in the development of these cognitive impairments. Despite these findings, the precise mechanisms by which anesthesia and surgery contribute to sleep disturbances and subsequently to PND remain inadequately understood. Addressing these gaps is essential for developing targeted interventions and optimizing clinical care pathways to mitigate the impact of PND.
This research topic aims to enhance our understanding of the intricate relationship between post-operative neurocognitive disorder and sleep disturbances. By investigating the underlying biochemical and neurophysiological mechanisms, as well as the role of inflammatory responses, melatonin, and circadian rhythms, this research seeks to identify potential interventions. The goal is to explore how anesthetic techniques, effective pain management, and targeted sleep interventions can be optimized to prevent or reduce the incidence of PND.
To gather further insights into the complex interplay between PND and sleep disturbances, we welcome articles addressing, but not limited to, the following themes:
- Advances in understanding the genetic, hormonal, neurotransmitter, endocrine, and molecular factors influencing the relationship between PND and sleep disturbances.
- Comprehensive assessment of treatment effects, including the impact of combined therapeutic approaches such as pharmacological and physiotherapeutic interventions.
- Exploration of novel treatment strategies and techniques, focusing on innovative preventive and therapeutic approaches to manage PND and associated sleep disturbances.
This research topic aims to enhance our understanding of the intricate relationship between post-operative neurocognitive disorder and sleep disturbances. By investigating the underlying biochemical and neurophysiological mechanisms, as well as the role of inflammatory responses, melatonin, and circadian rhythms, this research seeks to identify potential interventions. The goal is to explore how anesthetic techniques, effective pain management, and targeted sleep interventions can be optimized to prevent or reduce the incidence of PND.
To gather further insights into the complex interplay between PND and sleep disturbances, we welcome articles addressing, but not limited to, the following themes:
- Advances in understanding the genetic, hormonal, neurotransmitter, endocrine, and molecular factors influencing the relationship between PND and sleep disturbances.
- Comprehensive assessment of treatment effects, including the impact of combined therapeutic approaches such as pharmacological and physiotherapeutic interventions.
- Exploration of novel treatment strategies and techniques, focusing on innovative preventive and therapeutic approaches to manage PND and associated sleep disturbances.
Keywords: neurocognitive disorder, sleep disturbances, general anesthesia, analgesia management, biochemical and neurophysiological mechanisms
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
