Gut and oral microbiota orchestrate critical roles in human health. Gut and oral microbiome often crosstalk through a complex ‘oral-gut axis’ network. The beneficial microbiota helps maintain overall health by protecting against pathogens, promoting immune system functioning, and aiding digestion. On the contrary, oral and gut dysbiosis, a shift from healthy to pathogenic microbiota, leads to diseases that include obesity, cancers, diabetes, inflammatory bowel diseases, mental issues, periodontal diseases, dental caries, and autoimmune diseases, among others. Numerous factors contribute to the abnormalities in the oral microbiota, such as dietary habits, smoking, oral hygiene, gingival inflammation, etc. In contrast, unhealthy diets, poor hygiene, and improper use of medications disrupt the gut microbiome. A varied and chronic cause that connects oral-gut dysbiosis involves physical and psychological stresses.

The research topic aims to discuss the effects of oral and gut microbiota on health and the disruption that leads to aberrations. This topic will be a platform to showcase cutting-edge research to address outstanding questions and knowledge gaps, provide mechanistic insights, and attempt to contribute solutions related to oral and gut microbiome.

This topic invites high-quality research papers, review articles, mini-reviews, brief reports, systematic reviews, perspectives, methods, and opinions involving all aspects of oral and gut microbiome in health and diseases. Within this scope of oral and gut microbiome, topics of specific interest include, but are not limited to:

● Identification and characterization of beneficial or dysbiosis microbial communities in individuals
● Understanding cause-effect relationships between microbial communities and health or diseases
● Mechanistic underpinnings of oral and gut microbiota involvements in health promotion and pathogenesis
● The microbial interplay and complex microbial network that determine health maintenance or disease progression
● Oral-gut microbiota crosstalk in health and disease
● Impact of stress on oral and gut microbiome
● Studies on Synthetic microbial communities (SynComs) to fight dysbiosis
● Oral-gut microbiota modulation, development of novel probiotics and precision medicines to reverse microbial dysbiosis

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Frontiers in Cellular and Infection Microbiology

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