Polyphenols as Potent Modulators of Inflammation-Associated Non-Communicable Diseases

Polyphenols are a diverse group of phytochemicals with over 8,000 identified structures, primarily sourced from plants like cereals, fruits, and vegetables. These compounds are significant for their phenolic structures and multiple hydroxyl groups, which define their antioxidant properties. The intricacies of their absorption in the small intestine, subsequent metabolism in the liver and intestines, and the transformative actions of gut microbiota in the colon, highlight their complex biological roles. Despite advances in understanding, the complete scope of their effects, especially in the context of non-communicable diseases (NCDs) such as cancers, cardiovascular diseases, and metabolic disorders, remains partially elucidated.

This Research Topic aims to explore the influence of polyphenols on inflammation pathways integral to NCDs, focusing on their potential as anti-inflammatory and redox modulating agents. Investigations will extend to their interaction with cellular signaling pathways, notably the NF-κB pathway, to unveil how they might contribute to NCDs prevention and therapy.

We invite contributions that delve into the molecular and clinical dimensions of polyphenols in relation to inflammation-driven NCDs. This special issue aims to broaden the research horizon in the following key areas:

• Cardiovascular diseases
• Metabolic disturbances
• Oncological conditions
• Microbial composition of the gut
• Intracellular signaling dynamics
• Clinical research outcomes
• Empirical studies from in vivo, in vitro, and in silico models

These topics are expected to enrich the discussion on dietary polyphenols, showcasing their potential in medical and dietary strategies against NCDs, contributing significantly to global health improvement initiatives.