About this Research Topic
A bacterial biofilm is a cluster of immobile bacterial communities where cells are enclosed in a self-produced polymeric matrix that adheres to surfaces. It comprises of bacterial population by extra-cellular matrix (ECM) which possesses bacterial secreted polymers such as exopolysaccharides (EPS), extracellular DNA (e-DNA), proteins, and amyloidogenic proteins. Bacterial biofilms are a serious global health concern due to their ability to not only provide protection against altered pH, osmolarity, nutrient scarcity, mechanical and shear forces but also tolerate antibiotics and host defense systems, contribute to persistent chronic infections compared to their planktonic (free-living) counterparts.
The goal of study is to dissect the biochemical pathways and structural features contributing to biofilm resistance and to simulate these processes through computational in silico (computational) approaches. The expected outcomes of this research include a detailed characterization of biofilm architecture, identification of critical biochemical and genetic factors involved in resistance, and validated computational models that predict biofilm behavior under various conditions. Ultimately, the study aims to propose novel therapeutic strategies to disrupt biofilm formation and improve antibiotic efficacy, thereby addressing a critical issue in infectious disease management and contributing to improved clinical outcomes.
This interdisciplinary approach offers a holistic view of biofilm resilience, paving the way for innovative treatments and enhanced patient care by providing insights into the development of more effective strategies to manage and eradicate biofilm-related infections.
We welcome contributions relating to the following sub-themes:
1. Biofilm Formation and Development
Information for Authors: Studies will explore the stages of biofilm development, key molecular players, and the biochemical pathways involved in the formation and maintenance of biofilms.
2. Antibiotic Resistance in Biofilms
Information for Authors: Study will address how biofilms enhanced resistance to antibiotics, including both intrinsic and acquired mechanisms. Comparative studies with planktonic cells are encouraged.
3. Biochemical and Molecular Characterization
Information for Authors: Study will pave in-depth biochemical analysis of bacterial biofilm , highlighting novel components and their roles in resilience against antibiotics.
4. In Silico Approaches and Computational Modeling
Information for Authors: Study will include computational methods such as bioinformatics analyses, predictive modeling, and molecular dynamics simulations to understand biofilm resilience.
5. Innovative Antimicrobial Strategies
Information for Authors: Submissions will propose and evaluate new strategies to overcome biofilm-associated antibiotic resistance, including the repurposing of existing drugs and combination therapies.
6. Emerging Technologies and Methodologies
Information for Authors: Research topic will introduce novel technologies and methodologies that enhance the study of biofilms, including improvements in data acquisition, analysis, and interpretation.
The goal of study is to dissect the biochemical pathways and structural features contributing to biofilm resistance and to simulate these processes through computational in silico (computational) approaches. The expected outcomes of this research include a detailed characterization of biofilm architecture, identification of critical biochemical and genetic factors involved in resistance, and validated computational models that predict biofilm behavior under various conditions. Ultimately, the study aims to propose novel therapeutic strategies to disrupt biofilm formation and improve antibiotic efficacy, thereby addressing a critical issue in infectious disease management and contributing to improved clinical outcomes.
This interdisciplinary approach offers a holistic view of biofilm resilience, paving the way for innovative treatments and enhanced patient care by providing insights into the development of more effective strategies to manage and eradicate biofilm-related infections.
We welcome contributions relating to the following sub-themes:
1. Biofilm Formation and Development
Information for Authors: Studies will explore the stages of biofilm development, key molecular players, and the biochemical pathways involved in the formation and maintenance of biofilms.
2. Antibiotic Resistance in Biofilms
Information for Authors: Study will address how biofilms enhanced resistance to antibiotics, including both intrinsic and acquired mechanisms. Comparative studies with planktonic cells are encouraged.
3. Biochemical and Molecular Characterization
Information for Authors: Study will pave in-depth biochemical analysis of bacterial biofilm , highlighting novel components and their roles in resilience against antibiotics.
4. In Silico Approaches and Computational Modeling
Information for Authors: Study will include computational methods such as bioinformatics analyses, predictive modeling, and molecular dynamics simulations to understand biofilm resilience.
5. Innovative Antimicrobial Strategies
Information for Authors: Submissions will propose and evaluate new strategies to overcome biofilm-associated antibiotic resistance, including the repurposing of existing drugs and combination therapies.
6. Emerging Technologies and Methodologies
Information for Authors: Research topic will introduce novel technologies and methodologies that enhance the study of biofilms, including improvements in data acquisition, analysis, and interpretation.
Keywords: microbial resilience, Biofilm Formation, Antibiotic Resistance, In Silico Modeling, Quorum Sensing, Microbial Pathogenesis
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
