Background and Rationale: Hepatitis continues to be a significant global health challenge, affecting millions of individuals across the world. World Hepatitis Day 2024 highlights the ongoing efforts to eliminate hepatitis as a public health threat by 2030—a target set by the World Health Organization. Despite substantial advancements in the prevention, diagnosis, and treatment of hepatitis, critical gaps remain in our understanding and management of the disease.

To commemorate World Hepatitis Day 2024, this Research Topic aims to consolidate recent scientific advancements and foster innovative research in the field of hepatitis. Emphasizing multidisciplinary approaches and global perspectives, this compilation will serve as a catalyst for future research and policy development.

Scope and Aims: This Research Topic seeks to cover a broad spectrum of hepatitis-related research, highlighting both foundational science and clinical applications. Key themes include but are not limited to:

1. Epidemiology and Public Health Impact:
Global and regional epidemiological trends of hepatitis B, C, D, and E.
Socioeconomic and health system impacts of chronic hepatitis.
Strategies for achieving hepatitis elimination goals by 2030.
2. Pathogenesis and Immunology:
Molecular mechanisms of hepatitis virus infection and replication.
Host immune responses and mechanisms of viral persistence.
Novel biomarkers for early detection and disease progression.
3. Diagnostics and Therapeutics:
Advances in hepatitis diagnostic tools and technologies.
Innovations in antiviral therapies and their clinical efficacy.
Personalized medicine approaches in hepatitis treatment.
4. Vaccination and Prevention:
Development and deployment of new hepatitis vaccines.
Public health strategies to increase vaccination coverage.
Evaluating the long-term efficacy of hepatitis vaccines.
5. Liver Disease and Complications:
Pathophysiology of hepatitis-related liver fibrosis, cirrhosis, and hepatocellular carcinoma.
Management of co-infections and comorbidities in hepatitis patients.
Novel therapeutic approaches for liver disease complications.
6. Health Policy and Economics:
Cost-effectiveness of hepatitis intervention programs.
Policies for improving access to hepatitis care in low- and middle-income countries.
Impact of global health initiatives on hepatitis control.

Submission Guidelines: We invite researchers to submit original research articles, reviews, brief research reports, and clinical case studies. Submissions should be methodologically rigorous and provide significant insights into the field of hepatitis. Collaborative studies and those offering novel perspectives are particularly encouraged.

Expected Impact: This Research Topic is expected to make a substantial contribution to the field of hepatitis research by consolidating current knowledge and inspiring new investigative directions. By fostering a diverse and inclusive academic dialogue, we aim to accelerate scientific advancements and support the global effort to eradicate hepatitis as a public health threat.

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Frontiers in Gastroenterology

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