Homeostasis is a dynamic self-regulating process by which biological systems maintain a stable and constant status despite internal and/or external stimuli. It is a process to maintain dynamic equilibrium within a cell, an organ, and even the whole organism. Deciphering the molecular mechanisms underlying homeostasis at each level is critical for understanding diseases and aging.
Cellular signaling pathways, such as Wnt, Hedgehog, Dpp/BMP, and Notch signaling, play a fundamental role in animal development. However, how these pathways participate and engage in homeostasis is still not well understood. Upon stress or stimuli, signaling pathways could serve as sensors of cellular changes, guides of cellular processes, and controllers of cell behaviors. More importantly, more than one signaling pathways could be activated and they should work together to control tissue homeostasis. The aim of this Research Topic is to elucidate how various key signal pathways cooperate and integrate to maintain tissue homeostasis.
Therefore, this Research Topic welcomes submissions highlighting the functions and molecular mechanisms of signaling pathways during homeostasis at any level. We welcome contributions in the form of Original Research articles, Brief Research Reports, Reviews, and Mini Reviews that cover but are not limited to the following subtopics The subtopics including but not limited to:
• Exploring and identifying the critical components and regulators within the signal transduction pathway, specifically with a focus on their role in maintaining biological homeostasis;
• Investigating the specific function and impact of cellular signaling during tissue/organ development, and its implications for maintaining a stable and constant status in varying conditions;
• Deciphering the critical function of signaling for tissue/organ maintenance and survival upon exposure to stimuli or stress conditions, and its significance for homeostasis;
• Investigating the role of signaling pathways, such as Wnt, Hedgehog, Dpp/BMP, and Notch, in aging and disease development, progression, with particular emphasis on their contribution to homeostasis;
• Investigating how multiple signaling pathways collaborate and integrate in response to stresses or stimuli to maintain tissue homeostasis.
Keywords:
signaling pathway, homeostasis, organ development, organ maintenance, stress
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
Homeostasis is a dynamic self-regulating process by which biological systems maintain a stable and constant status despite internal and/or external stimuli. It is a process to maintain dynamic equilibrium within a cell, an organ, and even the whole organism. Deciphering the molecular mechanisms underlying homeostasis at each level is critical for understanding diseases and aging.
Cellular signaling pathways, such as Wnt, Hedgehog, Dpp/BMP, and Notch signaling, play a fundamental role in animal development. However, how these pathways participate and engage in homeostasis is still not well understood. Upon stress or stimuli, signaling pathways could serve as sensors of cellular changes, guides of cellular processes, and controllers of cell behaviors. More importantly, more than one signaling pathways could be activated and they should work together to control tissue homeostasis. The aim of this Research Topic is to elucidate how various key signal pathways cooperate and integrate to maintain tissue homeostasis.
Therefore, this Research Topic welcomes submissions highlighting the functions and molecular mechanisms of signaling pathways during homeostasis at any level. We welcome contributions in the form of Original Research articles, Brief Research Reports, Reviews, and Mini Reviews that cover but are not limited to the following subtopics The subtopics including but not limited to:
• Exploring and identifying the critical components and regulators within the signal transduction pathway, specifically with a focus on their role in maintaining biological homeostasis;
• Investigating the specific function and impact of cellular signaling during tissue/organ development, and its implications for maintaining a stable and constant status in varying conditions;
• Deciphering the critical function of signaling for tissue/organ maintenance and survival upon exposure to stimuli or stress conditions, and its significance for homeostasis;
• Investigating the role of signaling pathways, such as Wnt, Hedgehog, Dpp/BMP, and Notch, in aging and disease development, progression, with particular emphasis on their contribution to homeostasis;
• Investigating how multiple signaling pathways collaborate and integrate in response to stresses or stimuli to maintain tissue homeostasis.
Keywords:
signaling pathway, homeostasis, organ development, organ maintenance, stress
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.