Gene editing refers to the precise alteration of an organism's DNA sequence at a specific locus. In cancer treatment, this technology is leveraged to modify the genetic makeup of cancer cells, either to disable oncogenes or to restore tumor suppressor gene function. Common gene editing tools include CRISPR-Cas9, TALENs, and ZFNs, with CRISPR-Cas9 being the most widely used due to its simplicity, efficiency, and versatility. Nonetheless, current gene editing methods face significant challenges, such as off-target effects, immunogenicity, and delivery efficiency. Future research, including but not limited to the development of delivery systems, is critically needed to overcome these challenges.

This research topic aims to explore the latest advances and future trends in cancer gene therapy, with a particular focus on the application of gene editing technologies like CRISPR-Cas9. The objective is to highlight recent research achievements and assess the potential benefits of these technologies in enhancing the efficacy of cancer treatments while minimizing adverse effects. We seek to address key questions such as how to improve the precision and delivery of gene editing tools and how these technologies can be integrated into personalized cancer treatment protocols. By fostering a multidisciplinary approach, this research topic aims to advance our understanding of gene editing in cancer therapy and its implications for clinical practice.

To gather further insights into the realm of cancer gene therapy, we welcome articles addressing, but not limited to, the following themes:

1. The development of novel gene editing tools, methods, and systems in cancer therapy
2. The improvement of delivery vectors and delivery systems for gene editing in cancer therapy
3. Personalized customization of treatment protocols for gene editing in cancer therapy
4. The application of nanomedicine in cancer gene therapy
5. Mechanisms of therapeutic gene editing tools
6. Regulatory issues, ethics and equity of access for patients

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Frontiers in Medicine

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