Mesenchymal Stem Cells (MSCs) are multipotent stromal cells with the unique ability to differentiate into a variety of cell types, including osteoblasts, chondrocytes, and adipocytes. This versatility makes MSCs an invaluable resource for repairing damaged tissues and organs. Discovered in the 1960s, MSCs have since garnered significant interest for their potential in regenerative medicine and tissue engineering. These cells are primarily found in the bone marrow but can also be isolated from other tissues such as adipose tissue, umbilical cord blood, and dental pulp.

One of the key features of MSCs is their immunomodulatory properties, which allow them to alter immune responses and reduce inflammation. This makes them promising candidates for treating a range of inflammatory and autoimmune conditions. In addition, their ability to migrate to sites of injury and secrete bioactive molecules that promote tissue repair further enhances their therapeutic potential.

Research into MSCs has expanded rapidly, exploring their use in treating conditions such as osteoarthritis, cardiovascular diseases, and spinal cord injuries. Clinical trials are ongoing to determine the safety and efficacy of MSC-based therapies. Moreover, advancements in biotechnology have led to the development of methods to enhance MSC functionality and viability, improving their therapeutic outcomes.

Therefore, this Research Topic aims to provide a comprehensive, contemporary collection of research that focus on role of mesenchymal stem cells. We welcome Original Research Articles, Reviews, Mini-Reviews, Systematic Reviews, Perspectives, Commentaries, Data notes, and technical notes, but are not limited to the following:

• Research demonstrates MSCs' ability to differentiate into various cell types, such as osteoblasts, chondrocytes, and adipocytes, crucial for tissue repair.
• Studies that reveal MSCs can modulate immune responses, reducing inflammation and enhancing healing processes in damaged tissues.
• Research on MSCs in Liver and Cardiac and Orthopedic applications.
• Advances in tissue engineering incorporate MSCs with scaffolds and biomaterials, enhancing their survival, differentiation, and integration into damaged tissues for more effective regeneration therapies.

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Frontiers in Bioengineering and Biotechnology

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