Molecular imaging has the potential to change the landscape of clinical trials, offering unprecedented insights from patient selection to response evaluation. By enabling early and precise disease detection and characterization, molecular imaging facilitates the identification of suitable trial participants, ensuring that patients most likely to benefit are accurately selected. This non-invasive approach leverages advanced molecular imaging to visualize and quantify biological processes at the molecular and cellular levels.

Throughout the trial, molecular imaging can provide real-time monitoring of therapeutic efficacy and disease progression, enhancing the assessment of treatment responses. Criteria such as PERCIST (PET Response Criteria in Solid Tumors) are already implemented for this purpose, standardizing response evaluation and improving comparability across studies. By integrating molecular imaging, clinical trials can achieve more accurate and timely insights into patient responses, ultimately accelerating the development of personalized medicine and improving patient outcomes.

The goal of this research collection is to gather and present a comprehensive array of articles that explore the use of molecular imaging within clinical trials, highlighting its potential to transform trial patient management and therapeutic outcomes evaluation. This collection aims to investigate current applications of molecular imaging in clinical trials, emphasizing its role in improving patient selection, monitoring therapeutic efficacy, and evaluating treatment responses.

Additionally, this collection seeks to advance the field by encouraging the development of new guidelines, methodologies, and imaging protocols that can enhance the accuracy and utility of molecular imaging in clinical trial settings.

Moreover, the collection will spotlight cutting-edge advancements in imaging techniques and the identification of novel imaging targets that can further refine the precision and effectiveness of novel drugs, and drugs comparison, within the context of clinical trials. By fostering research that bridges the gap between imaging technologies and clinical applications, this collection aspires to accelerate the integration of molecular imaging into routine trial practices.

Through this collaborative effort, we hope to stimulate dialogue, inspire innovation, and pave the way for future breakthroughs in the field of molecular imaging within clinical trials.

We invite contributors to address the following specific themes:

1. Patient Selection: Utilizing molecular imaging for precise identification of trial participants.

2. Therapeutic Monitoring: Real-time assessment of therapeutic efficacy and disease progression using imaging techniques.

3. Response Evaluation: Creating and/or implementation of standardized criteria in clinical trials, studying of existing criteria.

4. Guideline Development: Advancing guidelines and protocols for the integration of molecular imaging in clinical trials.

5. Technological Innovations: Exploration of new imaging techniques and novel molecular targets to improve current usage of imaging in clinical trials.

We welcome a variety of manuscript types, including original research articles, review papers, as well as clinical trial reports, and perspectives. This collection aims to foster interdisciplinary collaboration and innovation in the application of molecular imaging within clinical trials. We strongly encourage contributors to adhere to established guidelines (STROBE, REMARK, PRISMA, etc.).

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Frontiers in Nuclear Medicine

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