About this Research Topic
Metabolic products of both the host and the microbiome have a widely demonstrated impact on regulating the immune system and immunometabolism. Some examples of metabolites are short-chain fatty acids (SCFAs), polyamines, tryptophan indole derivatives, conjugated linoleic acids (CLAs), and hippuric acid. Pivotally, some metabolites are adsorbed and circulate in the blood at levels as pharmaceutical drugs, obviously affecting host physiology. Many products are associated with anti-inflammatory effects through NFkB blockade, binding and activation of xenobiotic receptors such as Aryl hydrocarbon receptor (AhR) and pregnane X receptor (PXR) or with cell proliferation and host mucosal repair, influencing host cell signaling and gene expression. It is still to be deeply investigated which molecules are crucial in this regulatory network, which are the physiological and pathogenic concentrations of those products that may predispose to metabolic-mediated diseases, and how the host genetic background may affect the overall co-metabolism.
Advances in metabolomics and system immunology methodologies helped answer major questions and uncover essential host and microbial networks previously under-investigated. These networks now explain novel mechanisms based on different pathologies, such as autoimmune disorders and cancer.
Despite these advances, many questions about the complex interactions of the microbiome metabolism and the host metabolism remain unanswered. One important aspect under investigation is the fate of many microbial and host metabolic products and how they intercept metabolic interactions in health and disease.
In this research topic, we embark on a journey to explore novel metabolic networks between the host and the microbiome, previously uncharted territories. The potential of these discoveries to provide answers to crucial questions about immunometabolism is truly inspiring and holds the promise of revolutionizing our understanding of this field. This knowledge will help us understand how metabolic products may be used as possible biomarkers, therapeutic targets, and evolutionary studies.
The aim of this Research Topic is to focus on novel metabolic interconnections between the host and the microbiome.
Authors are encouraged to contribute original scientific articles, reviews, and mini-reviews focusing on the following areas:
- Host-microbiome immune co-interactions
- Host-microbiome metabolomics
- Host-microbiome co-metabolism
- Host-microbiome co-shaping
Teresa Zelante, Marco Gargaro and Francesca Fallarino are employed by the University of Perugia. All the other topic editors declare no conflict of interest
Advances in metabolomics and system immunology methodologies helped answer major questions and uncover essential host and microbial networks previously under-investigated. These networks now explain novel mechanisms based on different pathologies, such as autoimmune disorders and cancer.
Despite these advances, many questions about the complex interactions of the microbiome metabolism and the host metabolism remain unanswered. One important aspect under investigation is the fate of many microbial and host metabolic products and how they intercept metabolic interactions in health and disease.
In this research topic, we embark on a journey to explore novel metabolic networks between the host and the microbiome, previously uncharted territories. The potential of these discoveries to provide answers to crucial questions about immunometabolism is truly inspiring and holds the promise of revolutionizing our understanding of this field. This knowledge will help us understand how metabolic products may be used as possible biomarkers, therapeutic targets, and evolutionary studies.
The aim of this Research Topic is to focus on novel metabolic interconnections between the host and the microbiome.
Authors are encouraged to contribute original scientific articles, reviews, and mini-reviews focusing on the following areas:
- Host-microbiome immune co-interactions
- Host-microbiome metabolomics
- Host-microbiome co-metabolism
- Host-microbiome co-shaping
Teresa Zelante, Marco Gargaro and Francesca Fallarino are employed by the University of Perugia. All the other topic editors declare no conflict of interest
Keywords: Metabolites, Postbiotics, Microbiome, Immunometabolism, Tolerance, Xenobiotic Receptors
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
