About this Research Topic
Alzheimer’s disease (AD) and associated dementias pose complex obstacles in the development of therapeutic interventions, particularly within heterogeneous populations. Elucidating the intricate relationship between beta-amyloid and tau is essential for unravelling the pathogenesis of Alzheimer’s disease, and explaining the challenges and failures encountered in previous therapeutic approaches. Investigating Aβ-induced tau pathology across diverse populations can shed light on the underlying causes of these disparities and guide efforts to mitigate them. This Research Topic aims to encompass diverse populations, which may contribute to a more comprehensive understanding of the disease’s global impact. Committed to freely disseminating high-quality research and facilitating global collaboration, Frontiers in Molecular Neuroscience seeks to accelerate progress in this field and advance the principles of Open Science.
This Research Topic aims to underscore the significance of integrating multi-omics data analyses, encompassing genomics, transcriptomics, proteomics, and metabolomics, in unraveling the molecular underpinnings of Alzheimer’s disease and related dementias across diverse populations. We invite researchers globally to contribute their original research, reviews, and perspectives to this endeavor. Collectively, let us strive to deepen our understanding of these complex disorders, embracing the diversity of our investigations and paving the way for more inclusive and effective strategies to combat them.
The outcomes of this research hold promise for advancing our understanding of Alzheimer’s disease and related dementias. Establishing a centralized repository of integrated multi-omics data will provide invaluable resources for researchers to explore various aspects of AD pathology. Furthermore, elucidating both commonalities and disparities in disease presentation across populations can enhance the generalizability of research findings. While original research and review articles utilizing multi-omics data analysis are welcome, studies focusing on the following areas are of particular interest:
1. Identification of novel biomarkers for Alzheimer's disease and related dementias in diverse populations.
2. Investigation of the genetic and molecular mechanisms underlying the progression of Alzheimer's disease in different patient groups.
3. Development of personalized therapeutic approaches tailored to the genetic backgrounds of diverse populations.
4. Exploration of the role of epigenetic modifications in the pathogenesis and progression of Alzheimer's disease.
5. Integration of multi-omics data to elucidate the interactions between genetic, environmental, and lifestyle factors in Alzheimer's disease risk and progression.
This Research Topic aims to underscore the significance of integrating multi-omics data analyses, encompassing genomics, transcriptomics, proteomics, and metabolomics, in unraveling the molecular underpinnings of Alzheimer’s disease and related dementias across diverse populations. We invite researchers globally to contribute their original research, reviews, and perspectives to this endeavor. Collectively, let us strive to deepen our understanding of these complex disorders, embracing the diversity of our investigations and paving the way for more inclusive and effective strategies to combat them.
The outcomes of this research hold promise for advancing our understanding of Alzheimer’s disease and related dementias. Establishing a centralized repository of integrated multi-omics data will provide invaluable resources for researchers to explore various aspects of AD pathology. Furthermore, elucidating both commonalities and disparities in disease presentation across populations can enhance the generalizability of research findings. While original research and review articles utilizing multi-omics data analysis are welcome, studies focusing on the following areas are of particular interest:
1. Identification of novel biomarkers for Alzheimer's disease and related dementias in diverse populations.
2. Investigation of the genetic and molecular mechanisms underlying the progression of Alzheimer's disease in different patient groups.
3. Development of personalized therapeutic approaches tailored to the genetic backgrounds of diverse populations.
4. Exploration of the role of epigenetic modifications in the pathogenesis and progression of Alzheimer's disease.
5. Integration of multi-omics data to elucidate the interactions between genetic, environmental, and lifestyle factors in Alzheimer's disease risk and progression.
Keywords: Alzheimer's disease, beta-amyloid and tau, dementias, multi-omics
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
