About this Research Topic
Nanotechnology has increasingly permeated the food and agrichemical sectors, leading to widespread human exposure to dietary nanoparticles (NPs). These NPs, including nano-clays, metal nanoparticles, and nanocomposites, are heralded for their roles in enhancing food safety through improved pathogen and pollutant detection and extending product shelf life. Moreover, applications such as allergen-encapsulating polymeric NPs aim at reprogramming immune responses towards tolerogenic pathways, mirroring the effects of allergen-specific immunotherapy. Despite these innovations, the safety of chronic NP exposure in food remains poorly understood.
This Research Topic aims to elucidate the mechanisms by which nanoparticles contribute to the development and exacerbation of food allergies. Primary objectives include examining the implications of NP-mediated alteration of the intestinal barrier, interactions with the immune system, their potential effects on the gut microbiota, and the subsequent impact on immune regulation and disease development. Additionally, we seek to explore how chronic exposure to NPs might provoke or intensify food allergies through various biological pathways.
To gather further insights into these phenomena, we welcome articles focusing on but not limited to the following themes:
- Impact of chronic exposure to NPs on the pathobiology and pathophysiology of food allergies.
- Effects of NPs on the intestinal immune response and oral tolerance induction.
- Interactions between NPs, the intestinal tract, and gut microbiota.
- Comprehensive "in vivo" and "in vitro" studies assessing NP toxicity.
This Research Topic aims to elucidate the mechanisms by which nanoparticles contribute to the development and exacerbation of food allergies. Primary objectives include examining the implications of NP-mediated alteration of the intestinal barrier, interactions with the immune system, their potential effects on the gut microbiota, and the subsequent impact on immune regulation and disease development. Additionally, we seek to explore how chronic exposure to NPs might provoke or intensify food allergies through various biological pathways.
To gather further insights into these phenomena, we welcome articles focusing on but not limited to the following themes:
- Impact of chronic exposure to NPs on the pathobiology and pathophysiology of food allergies.
- Effects of NPs on the intestinal immune response and oral tolerance induction.
- Interactions between NPs, the intestinal tract, and gut microbiota.
- Comprehensive "in vivo" and "in vitro" studies assessing NP toxicity.
Keywords: Food allergy, food nanotechnology, dietary nanoparticles, metal-based nanoparticles, immune response, oxidative stress, oral tolerance, nanotoxicity, gut microbiome, intestinal barrier
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
