Tumor organoids refer to three-dimensional (3D) cell culture models obtained by culturing tissue from a patient's biopsy, puncture, or surgical resection in matrix gel for several weeks, forming microstructures in vitro that reflect various characteristics of the tumor in the patient's body. The development and application of organoid technology are of great significance to the research and clinical treatment of tumors. In the field of drug discovery, organoids have been extensively used to identify promising drug targets and test the efficacy and safety of potential drug candidates. As for drug sensitivity testing, organoids derived from patient samples can accurately predict the response of patients to drugs, with an accuracy rate greater than 80%. Advanced technologies are currently employed to expedite the cycle of PDO-based drug testing; one method involves reducing reaction volumes through the use of microfabricated array devices, and another method utilizes droplet emulsion microfluidics or an “organoids-on-a-chip” system with temperature control mechanisms. Evolutionary algorithms based on tumor organoid models can predict tumor evolution threads well. Therefore, tumor organoids make an excellent platform for personalized healthcare and drug development.
The goal of this research topic is to provide a platform to promote research on tumor personalized healthcare, Traditional Chinese medicine, and new drug screening and evaluation, basic theory research, and technology research using organoids, 3D culture, 3D printing, and microfluidics technologies. This research topic will also provide a comprehensive overview of the advancements, challenges, and potential impact of organoids, offering valuable insights for researchers. We aim to explain the connotation of tumor medicine healthcare with modern scientific methods, promoting the integration of traditional medicine into modern medicine.
We welcome submissions of Original Research Articles, Reviews, Mini-Reviews, Methods, and Perspectives that focus on, but are not limited to the following potential subtopics:
Applications of tumor organoids or 3D culture in the research of traditional medicine, such as the evaluation of pharmacodynamic and toxic effects, and further understanding of the mechanism of action.
Tumor organoids combining microfluidics, 3D printing, evolutionary algorithms, or the latest techniques to better mimic tumor occurrence and development.
Future trends and directives for research on tumor organoids, 3D culture, and tools in personalized healthcare.
Keywords:
Tumor organoids, 3D culture, Drug development, Personalized healthcare
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
Tumor organoids refer to three-dimensional (3D) cell culture models obtained by culturing tissue from a patient's biopsy, puncture, or surgical resection in matrix gel for several weeks, forming microstructures in vitro that reflect various characteristics of the tumor in the patient's body. The development and application of organoid technology are of great significance to the research and clinical treatment of tumors. In the field of drug discovery, organoids have been extensively used to identify promising drug targets and test the efficacy and safety of potential drug candidates. As for drug sensitivity testing, organoids derived from patient samples can accurately predict the response of patients to drugs, with an accuracy rate greater than 80%. Advanced technologies are currently employed to expedite the cycle of PDO-based drug testing; one method involves reducing reaction volumes through the use of microfabricated array devices, and another method utilizes droplet emulsion microfluidics or an “organoids-on-a-chip” system with temperature control mechanisms. Evolutionary algorithms based on tumor organoid models can predict tumor evolution threads well. Therefore, tumor organoids make an excellent platform for personalized healthcare and drug development.
The goal of this research topic is to provide a platform to promote research on tumor personalized healthcare, Traditional Chinese medicine, and new drug screening and evaluation, basic theory research, and technology research using organoids, 3D culture, 3D printing, and microfluidics technologies. This research topic will also provide a comprehensive overview of the advancements, challenges, and potential impact of organoids, offering valuable insights for researchers. We aim to explain the connotation of tumor medicine healthcare with modern scientific methods, promoting the integration of traditional medicine into modern medicine.
We welcome submissions of Original Research Articles, Reviews, Mini-Reviews, Methods, and Perspectives that focus on, but are not limited to the following potential subtopics:
Applications of tumor organoids or 3D culture in the research of traditional medicine, such as the evaluation of pharmacodynamic and toxic effects, and further understanding of the mechanism of action.
Tumor organoids combining microfluidics, 3D printing, evolutionary algorithms, or the latest techniques to better mimic tumor occurrence and development.
Future trends and directives for research on tumor organoids, 3D culture, and tools in personalized healthcare.
Keywords:
Tumor organoids, 3D culture, Drug development, Personalized healthcare
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.