About this Research Topic
Translational research and innovative therapies have greatly transformed the understanding of the most relevant pillars of atopic dermatitis (AD) pathogenesis: abnormal immune response, pruritus, cutaneous dysbiosis, and skin barrier defect. For instance, the immuno-inflammatory pathways of IL-13, IL-4R, OX40-axis, IL-31 and IL-22 have proven relevance in the clinic. Novel mechanisms in neuroimmunology of the skin have revolutionized pruritus understanding and management. Staphylococcus aureus is a key player in different aspect of AD. Interestingly, all these mechanisms are closely related to the itch-scratch cycle and skin barrier defects. All this transformative knowledge is supported by the introduction of cutting edge “omic” technologies in the clinical characterization of AD and the effect of targeted therapies that has allowed a complete molecular picture of the disease.
These research themes are designed to contribute significantly to the biomedical understanding of AD with potential clinical relevance. They aim to explore the growing complexities in AD, including the development of novel therapies such as targeted treatments and small molecules. Specifically, these topics address patient heterogeneity—both clinical and molecular—varied responses to targeted therapies, new mechanisms for AD treatment, the role of microorganisms in AD, and the identification and functional application of biomarkers to guide clinical decisions.
The scope of this Research Topic includes a comprehensive exploration of the translational research of AD. We invite authors to contribute with Original Research articles, Review papers, Clinical Case studies, and Perspectives that address key themes within this field. Specific areas of interest include, but are not limited to:
-Molecular and cellular mechanisms related to abnormal immune response, pruritus, cutaneous dysbiosis, and skin barrier defect.
-Novel concepts/mechanism in neuroimmunology of AD
-Innovative mechanism of action for AD management
-Molecular studies applying omic technologies that allow understanding the complex pathogenesis of AD.
-Biomarkers in the broad sense of applicability.
These research themes are designed to contribute significantly to the biomedical understanding of AD with potential clinical relevance. They aim to explore the growing complexities in AD, including the development of novel therapies such as targeted treatments and small molecules. Specifically, these topics address patient heterogeneity—both clinical and molecular—varied responses to targeted therapies, new mechanisms for AD treatment, the role of microorganisms in AD, and the identification and functional application of biomarkers to guide clinical decisions.
The scope of this Research Topic includes a comprehensive exploration of the translational research of AD. We invite authors to contribute with Original Research articles, Review papers, Clinical Case studies, and Perspectives that address key themes within this field. Specific areas of interest include, but are not limited to:
-Molecular and cellular mechanisms related to abnormal immune response, pruritus, cutaneous dysbiosis, and skin barrier defect.
-Novel concepts/mechanism in neuroimmunology of AD
-Innovative mechanism of action for AD management
-Molecular studies applying omic technologies that allow understanding the complex pathogenesis of AD.
-Biomarkers in the broad sense of applicability.
Keywords: atopic dermatitis, immunology, neuroimmunology, translational research, skin dysbiosis
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
