About this Research Topic
Autoimmune disease is characterized by a complex immunopathogenesis which involves an interplay of various factors including genetics, microbiomes, and environmental influences.
Rapid advances in genomic research have led to the identification of various genes associated with autoimmunity and their associated immune pathways. Meanwhile, gut microbiota and environmental influences play a pivotal role in autoimmunity by influencing the balance between immune activation and suppression. Gut microbial imbalance has been implicated in triggering autoimmune responses by altering immune cell development, cytokine profiles, and mucosal barrier integrity.
Environmental factors such as viral infections, diet, chemical exposures, and stressors contribute significantly to the onset and progression of autoimmunity. These factors can modify immune responses, trigger molecular mimicry, or disrupt immune tolerance mechanisms, which are the hallmark of autoimmunity.
Autoimmunity is a chronic and debilitating disease that carries significant morbidity and mortality. The exact cause of autoimmunity remains elusive, yet emerging data suggest a complex interplay of genetic predispositions, microbiome dynamics, and environmental influences. The wide spectrum of clinical phenotypes of autoimmune diseases is likely attributable to interactions among genetics, microbiomes, and environmental factors. Understanding how genetics, microbiomes, and environmental factors interact to influence the diversity in the clinical manifestations, disease progression, and outcome of autoimmune diseases is pivotal in unraveling the underlying mechanisms and potentially devising targeted therapeutic strategies.
This Research Topic will focus on;
Elucidating the interactions between genetics, microbiomes, and environment is crucial with their clinical implications
Rapid advances in genomic research have led to the identification of various genes associated with autoimmunity and their associated immune pathways. Meanwhile, gut microbiota and environmental influences play a pivotal role in autoimmunity by influencing the balance between immune activation and suppression. Gut microbial imbalance has been implicated in triggering autoimmune responses by altering immune cell development, cytokine profiles, and mucosal barrier integrity.
Environmental factors such as viral infections, diet, chemical exposures, and stressors contribute significantly to the onset and progression of autoimmunity. These factors can modify immune responses, trigger molecular mimicry, or disrupt immune tolerance mechanisms, which are the hallmark of autoimmunity.
Autoimmunity is a chronic and debilitating disease that carries significant morbidity and mortality. The exact cause of autoimmunity remains elusive, yet emerging data suggest a complex interplay of genetic predispositions, microbiome dynamics, and environmental influences. The wide spectrum of clinical phenotypes of autoimmune diseases is likely attributable to interactions among genetics, microbiomes, and environmental factors. Understanding how genetics, microbiomes, and environmental factors interact to influence the diversity in the clinical manifestations, disease progression, and outcome of autoimmune diseases is pivotal in unraveling the underlying mechanisms and potentially devising targeted therapeutic strategies.
This Research Topic will focus on;
Elucidating the interactions between genetics, microbiomes, and environment is crucial with their clinical implications
Keywords: Autoimmune, environment, genetics, immunopathogenesis, microbiomes
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