Volatile and intravenous general anesthetics encompass a diverse array of small and uncharged chemotypes including haloalkanes, haloethers and alkylphenols. Despite efforts reaching back over a century, clarification of their action mechanism has proven difficult and wanting. A favored hypothesis proposes that ion channels in the brain are implicated, among which members of ionotropic neurotransmitter receptors, voltage-gated and non-gated ion channels are best-known players. At the cellular level, mounting evidence supports that neocortical neurons synchronize their firing activity during various forms of general anesthesia, including loss and recovery of consciousness. Neocortical neurons, including interneurons, are therefore critical cellular targets for general anesthetics, largely implicated in one or more general anesthesia outcomes. Under construction...
In this Research Topic, Frontiers in Cellular Neuroscience is looking to address key aspects of “The role of neocortical neurons on general anesthesia” in order to promote the discussion around this topic and to facilitate knowledge dissemination. We particularly welcome submission of Original Research, Review, Methods, and Perspective articles including, but not limited to, the following sub-topics:
1) Molecular targets for general anesthetics: composition and cellular localization in neocortical neurons
2) Molecular mechanism of general anesthetics in neocortical neurons
3) Modulation of neocortical neurons by general anesthetics and implications for anesthesia outcomes, including loss and recovery of consciousness, sleep, memory loss and paralysis
4) Selective modulation of cellular subtypes of neocortical neurons by general anesthetics
5) The role of inhibitory interneurons on general anesthesia
6) Molecular basis for synchronized activity of neocortical neurons and implications for general anesthesia
Keywords:
general anesthetics, ion channels, neocortical neurons, inhibitory interneurons, synchronized activity, loss and recovery of consciousness
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
Volatile and intravenous general anesthetics encompass a diverse array of small and uncharged chemotypes including haloalkanes, haloethers and alkylphenols. Despite efforts reaching back over a century, clarification of their action mechanism has proven difficult and wanting. A favored hypothesis proposes that ion channels in the brain are implicated, among which members of ionotropic neurotransmitter receptors, voltage-gated and non-gated ion channels are best-known players. At the cellular level, mounting evidence supports that neocortical neurons synchronize their firing activity during various forms of general anesthesia, including loss and recovery of consciousness. Neocortical neurons, including interneurons, are therefore critical cellular targets for general anesthetics, largely implicated in one or more general anesthesia outcomes. Under construction...
In this Research Topic, Frontiers in Cellular Neuroscience is looking to address key aspects of “The role of neocortical neurons on general anesthesia” in order to promote the discussion around this topic and to facilitate knowledge dissemination. We particularly welcome submission of Original Research, Review, Methods, and Perspective articles including, but not limited to, the following sub-topics:
1) Molecular targets for general anesthetics: composition and cellular localization in neocortical neurons
2) Molecular mechanism of general anesthetics in neocortical neurons
3) Modulation of neocortical neurons by general anesthetics and implications for anesthesia outcomes, including loss and recovery of consciousness, sleep, memory loss and paralysis
4) Selective modulation of cellular subtypes of neocortical neurons by general anesthetics
5) The role of inhibitory interneurons on general anesthesia
6) Molecular basis for synchronized activity of neocortical neurons and implications for general anesthesia
Keywords:
general anesthetics, ion channels, neocortical neurons, inhibitory interneurons, synchronized activity, loss and recovery of consciousness
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.