The intricate networks of cytokines play a crucial role in modulating both autoimmune diseases and resistance to cancer therapies. In autoimmune diseases, cytokines such as TNF-α, IL-6, and IL-17 are pivotal in orchestrating the inflammatory response, often leading to tissue damage and disease progression. For instance, IL-17 has been implicated in the pathogenesis of rheumatoid arthritis and psoriasis by promoting the recruitment and activation of neutrophils and macrophages. These pro-inflammatory cytokines not only drive the autoimmune process but also create an environment conducive to chronic inflammation.

Conversely, in the context of cancer, the cytokine milieu within the tumor microenvironment can significantly influence the efficacy of anti-cancer therapies. Cytokines such as IL-10 and TGF-β are known to foster an immunosuppressive environment, aiding tumor cells in evading immune detection and contributing to drug resistance. Additionally, pro-inflammatory cytokines like IL-6 and IL-1β can enhance cancer cell survival, proliferation, and metastasis through various signaling pathways, including the STAT3 and NF-κB pathways. Understanding the dual roles of these cytokines in autoimmune pathogenesis and cancer therapy resistance is essential for developing novel therapeutic strategies aimed at modulating cytokine activity to treat autoimmune diseases and overcome resistance to cancer therapies.

The goal of this Research Topic is to provide a comprehensive platform for advancing our understanding of the complex role cytokine networks play in modulating autoimmune diseases and mediating resistance to anti-cancer therapies. By elucidating the specific mechanisms through which cytokines influence disease progression and treatment outcomes, this collection aims to foster the development of innovative therapeutic strategies that target cytokine activity, ultimately improving patient care in autoimmune and cancer treatment contexts.

This Research Topic explores the roles of cytokine networks in autoimmune disease modulation and anti-cancer drug resistance. Contributors should address:

- Mechanisms and Signaling Pathways of Cytokine-Mediated Inflammation: Studies on cytokines and signaling pathways in autoimmune diseases and cancer.
-Cytokine-Mediated Tumor Evasion and Drug Resistance: Research on immunosuppressive cytokines, tumor microenvironment cytokine profiles, and cytokine influence on immune cell recruitment, including strategies to modulate cytokine activity.
- Clinical Implications and Biomarkers: Identification of cytokine biomarkers for disease progression and treatment response.
- Combination Therapies: Efficacy studies of combining cytokine-targeted therapies with existing treatments.
- Innovative Therapeutic Approaches: Development of novel cytokine-based therapies and their preclinical and clinical evaluation.

We welcome original research, reviews, and clinical studies that offer novel therapeutic strategies targeting cytokine pathways. Submissions utilizing techniques like high-throughput screening, single-cell analysis, and advanced imaging to unravel cytokine interactions are highly valued. This topic aims to bridge basic research and clinical application, fostering interdisciplinary collaboration to improve treatment outcomes in autoimmune and cancer patients.

Submit your idea

Impact

Frontiers in Immunology

Submit your idea

Impact