During the last decade, technological advances made possible the high-throughput analysis of biologic molecules in immune skin conditions. This progress has led to the discovery of new pathogenic pathways, therapeutic targets, and revolutionary treatments. Multiomics approaches are under continuous development and include genomics, transcriptomics, metabolomics, proteomics, lipidomics, glycomics, epigenomics, microbiomics, nutriomics, exposome-omics, and others.
Multiomic approaches have the potential to achieve a holistic understanding of skin health and disease, starting from the physiological process of aging, to immune conditions with a great impact on worldwide morbidity and mortality such as psoriasis, atopic dermatitis, hidradenitis suppurativa or vesiculo-bullous autoimmune disorders. In oncologic patients, suffering either from skin cancer or from dermatologic adverse reactions to oncologic targeted therapies, the multiomics research may contribute to the discovery of key biomarkers or new molecular targets and improved outcomes.
While there have been tremendous advances made due to multiomics approaches, the high volume of information and the diversity of research often leads to divergent or conflicting results.
In this Research Topic, we aim to bring together, the most recent and relevant scientific studies focusing on the management of immune skin conditions (inflammatory, autoimmune, or with other complex immune pathogenic mechanisms) using multiomic approaches. We invite submissions that will provide readers with knowledge of recent advances, and novel discoveries contributing to the ultimate goal of bringing preclinical research to the bedside and providing precision medicine for patients.
This Research Topic welcomes contributions in the form of Original Research, Systematic Review, Review, Mini-Review, Clinical Trials, Case Reports, and others that focus on, but are not limited to, the following issues:
• The implementation of different OMIC approaches in the study of Immune skin conditions.
• The discovery of therapeutic targets in immune skin conditions through multiomics methodologies.
• Novel therapies that target immune pathogenic molecular pathways in skin conditions, with suppressive, regulatory, or stimulatory effects (e.g. immunotherapy, including biologic therapies or vaccines, therapies targeting the intracellular transmission pathways)
• Host-microbiome crosstalk in immune skin conditions
• Manipulation of pathogen-host crosstalk in the management of immune skin conditions (e.g. novel therapies, probiotics, prebiotics, cold plasma)
• New approaches for enhancing host immunity against infections based on pathogen-host crosstalk (e.g., preventing gut inflammation, utilizing microbial competitors such as probiotics, inducing nutritional shifts to restrict infectious diseases, understanding how antimicrobial resistance influences the anti-infectious host immune response for developing interventions to reduce colonization and transmission of antimicrobial-resistant bacteria, etc.)
Keywords:
precision medicine, immune skin conditions, biomarkers, multiomics approaches, genomics, transcriptomics, metabolomics, proteomics, lipidomics, glycomics, epigenomics, microbiomics, host-microbiome crosstalk, exposome-omics, immunotherapy, vaccine
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
During the last decade, technological advances made possible the high-throughput analysis of biologic molecules in immune skin conditions. This progress has led to the discovery of new pathogenic pathways, therapeutic targets, and revolutionary treatments. Multiomics approaches are under continuous development and include genomics, transcriptomics, metabolomics, proteomics, lipidomics, glycomics, epigenomics, microbiomics, nutriomics, exposome-omics, and others.
Multiomic approaches have the potential to achieve a holistic understanding of skin health and disease, starting from the physiological process of aging, to immune conditions with a great impact on worldwide morbidity and mortality such as psoriasis, atopic dermatitis, hidradenitis suppurativa or vesiculo-bullous autoimmune disorders. In oncologic patients, suffering either from skin cancer or from dermatologic adverse reactions to oncologic targeted therapies, the multiomics research may contribute to the discovery of key biomarkers or new molecular targets and improved outcomes.
While there have been tremendous advances made due to multiomics approaches, the high volume of information and the diversity of research often leads to divergent or conflicting results.
In this Research Topic, we aim to bring together, the most recent and relevant scientific studies focusing on the management of immune skin conditions (inflammatory, autoimmune, or with other complex immune pathogenic mechanisms) using multiomic approaches. We invite submissions that will provide readers with knowledge of recent advances, and novel discoveries contributing to the ultimate goal of bringing preclinical research to the bedside and providing precision medicine for patients.
This Research Topic welcomes contributions in the form of Original Research, Systematic Review, Review, Mini-Review, Clinical Trials, Case Reports, and others that focus on, but are not limited to, the following issues:
• The implementation of different OMIC approaches in the study of Immune skin conditions.
• The discovery of therapeutic targets in immune skin conditions through multiomics methodologies.
• Novel therapies that target immune pathogenic molecular pathways in skin conditions, with suppressive, regulatory, or stimulatory effects (e.g. immunotherapy, including biologic therapies or vaccines, therapies targeting the intracellular transmission pathways)
• Host-microbiome crosstalk in immune skin conditions
• Manipulation of pathogen-host crosstalk in the management of immune skin conditions (e.g. novel therapies, probiotics, prebiotics, cold plasma)
• New approaches for enhancing host immunity against infections based on pathogen-host crosstalk (e.g., preventing gut inflammation, utilizing microbial competitors such as probiotics, inducing nutritional shifts to restrict infectious diseases, understanding how antimicrobial resistance influences the anti-infectious host immune response for developing interventions to reduce colonization and transmission of antimicrobial-resistant bacteria, etc.)
Keywords:
precision medicine, immune skin conditions, biomarkers, multiomics approaches, genomics, transcriptomics, metabolomics, proteomics, lipidomics, glycomics, epigenomics, microbiomics, host-microbiome crosstalk, exposome-omics, immunotherapy, vaccine
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.