Cellular therapies are at the forefront of transformative treatment strategies for hematologic malignancies, offering new hope for patients with leukemia and myeloma. These therapies, which harness the power of the immune system or introduce genetically engineered cells, have shown unprecedented efficacy and potential for long-term remission. As the field evolves rapidly, ongoing advancements continue to push the boundaries, exploring novel approaches and refining existing ones to overcome challenges and improve patient outcomes.

The primary aim of this Research Topic is to explore the latest advancements and future directions in cellular therapies specifically designed for leukemia and myeloma. The focus will be on cutting-edge research, innovative clinical applications, and emerging technologies that have the potential to further revolutionize the treatment of these malignancies. We seek to address critical aspects such as patient selection, optimization of therapeutic protocols, management of side effects, and real-world application of these therapies. By bringing together diverse perspectives and findings, this issue aims to provide a comprehensive understanding that can inform clinical practice and guide future research.

We invite submissions that cover a wide range of themes related to advances and new horizons in cellular therapies for leukemia and myeloma, including but not limited to:

· Innovative Cellular Therapies: Detailed insights into novel cellular therapy approaches, such as next-generation CAR-T cells, TCR-engineered T cells, and dendritic cell vaccines, with a focus on their development and applications in leukemia and myeloma.

· Patient Selection and Clinical Outcomes: Criteria for selecting patients for different cellular therapies, comprehensive analyses of short-term and long-term outcomes, and strategies for optimizing treatment efficacy.

· Mechanisms of Action and Overcoming Resistance: In-depth studies on the biological mechanisms that cellular therapies use to target leukemia and myeloma cells, as well as innovative approaches to overcome resistance.

· Cutting-Edge Clinical Trials and Real-World Evidence: Updates on recent clinical trials, innovative trial designs, interim results, and real-world evidence to validate the safety and effectiveness of these therapies.

· Comparative Studies: Comparative assessments of different cellular therapies across various subtypes of leukemia and myeloma, identifying the most effective strategies for specific patient populations.

· Managing Side Effects and Supportive Care: Best practices for managing the unique side effects of cellular therapies and optimizing supportive care to enhance patient quality of life.

· Future Prospects and Emerging Research: Explorations of emerging research and technologies that promise to shape the next generation of cellular therapies and address current limitations.

Authors are encouraged to submit original research articles, comprehensive reviews, clinical trials, and methodological papers. Manuscripts must provide robust validation, either through independent cohorts or biological validation (in vitro or in vivo), to ensure scientific rigor. Bioinformatics or computational analyses without empirical validation will not be accepted. This Research Topic aims to provide valuable insights into the ongoing and future advancements in cellular therapies for leukemia and myeloma, aiding researchers, clinicians, and healthcare providers in their quest to improve patient outcomes.

Impact

Frontiers in Hematology

Gene Therapy, Cell Therapy and Hematology