Mechanopathology is an emerging field that explores the complex interactions between mechanical forces and tissue pathology. Historically, the mechanical environment of cells and tissues has been largely neglected in pathophysiological research. However, recent studies have highlighted the significant role that physical stress, such as load and strain, along with the deregulation of mechanosensitive proteins and altered mechanotransduction processes, play in the development and progression of various diseases. This growing body of evidence suggests that mechanical factors are crucial in understanding cellular dysfunction and tissue degeneration. Despite these advancements, there remains a gap in fully comprehending how these mechanical forces contribute to disease mechanisms. Current research is beginning to address these gaps, but a comprehensive understanding of the mechanical influences on disease etiology and management is still lacking, necessitating further investigation in this promising field.

This research topic aims to deepen our understanding of the mechanical influences on tissue pathology. By integrating biomechanics with cellular and molecular biology, the objective is to uncover the fundamental processes by which mechanical forces induce or exacerbate pathological states. The insights gained from this research could lead to innovative therapeutic approaches that target the mechanical environment of tissues, offering new avenues for the prevention, recognition, and treatment of pathological conditions. By addressing how mechanical stress affects cellular signaling, tissue integrity, and overall organ function, researchers can develop strategies that not only alleviate symptoms but also modify disease progression at a fundamental level.

To gather further insights in the mechanopathology field, we welcome articles addressing, but not limited to, the following themes:
- Cellular mechanotransduction pathways: Investigation into how cells sense and respond to mechanical stimuli.
- Biomechanical properties of diseased tissues: Studies on alterations in tissue stiffness, elasticity, and load-bearing capacity in pathological conditions.
- Mechanically-induced cellular dysfunction: Research on how mechanical stress leads to cellular injury, apoptosis, or altered metabolic states.
- Chronic mechanical overload and disease progression: Examination of how repetitive strain and mechanical overload contribute to chronic diseases such as osteoarthritis, tendinopathies, and heart failure.
- Regenerative medicine and mechanobiology: The use of mechanical stimuli in tissue engineering and regenerative approaches to restore tissue function and integrity.
- Emerging technologies in mechanopathological research: Utilization of cutting-edge technologies such as atomic force microscopy (AFM), microfluidics, and in vivo imaging to study mechanopathology.

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Frontiers in Cell and Developmental Biology

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