Skin aging is a multifaceted biological phenomenon influenced by an array of factors, including genetic, hormonal, metabolic, and environmental contributors. The aging process of the skin varies widely among individuals due to these intrinsic and extrinsic influences. Remarkably, genetic factors are dominant, accounting for about 60% of variability in skin aging, with specific genes responsible for crucial attributes like elasticity, hydration, and pigmentation—such as elastin, filaggrin, and melanocortin 1 receptor—playing significant roles in determining both intrinsic and extrinsic aging processes.

The business of anti-aging products, driven by genetic factors, has become extensive and lucrative. The variability in aging among individuals, particularly among different ethnicities, accentuates the need for a deeper understanding of genetic variations. Existing studies on this subject are limited, yet they offer valuable insights into the genetic mechanisms underpinning skin aging, often revealing unexpected results and actors. This topic seeks to thoroughly examine and correlate significant genes involved in aging across various models, proposing functional pathways that clarify the genetic basis of skin aging. Recent updates on genetic discoveries related to aging will also be discussed, with a focus on tailoring aesthetic protocols and clinical applications to individual needs.

To gather further insights into the genetic underpinnings of skin aging, we welcome articles addressing, but not limited to, the following themes:
o Novel genetic discoveries and their implications for skin elasticity, hydration, and pigmentation
o Mechanisms of genetic influence on individual and ethnic variability in skin aging
o Integrated approaches combining genetics with bioinformatics in skin aging research
o Personalized regenerative treatments based on genetic profiling
o The impact of environmental factors on genetically-driven skin aging processes
o The future of anti-aging products and therapies enriched by genetic insights

Through these submissions, we aim to deepen the understanding of skin aging, enhance personalized treatments, and further explore the genetic factors dictating this complex biological process.

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Frontiers in Genetics

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