Hematological malignancies, a subset of cancers affecting blood, bone marrow, and lymph nodes, present unique challenges due to the intricate nature of the bone marrow microenvironment. These malignancies are characterized by the rapid proliferation of tumor cells, which is facilitated by specific metabolic adaptations and immune evasion strategies. Such adaptations allow tumor cells to meet their energy demands while evading immune surveillance. The metabolic changes not only impact the tumor cells but also influence the immune cells within the bone marrow, thereby altering the tumor microenvironment. This, in turn, affects the growth, proliferation, drug resistance, and metastasis of the tumor cells. Despite significant advancements in understanding these processes, several critical questions remain unanswered. Key areas of inquiry include the specific metabolic adaptations of hematological malignancies, the mechanisms of immune escape, and the role of metabolism in therapeutic drug resistance. Addressing these questions is crucial for developing more effective treatments and understanding the unique metabolic and immunological landscape of hematological malignancies.

This research topic aims to deepen the understanding of the metabolism and immune microenvironment in hematological malignancies. The primary objectives include exploring the specific metabolic adaptations of tumor cells, understanding the crosstalk between tumor and immune cells, and investigating the mechanisms underlying immune escape and drug resistance. By fostering interdisciplinary collaboration, the research seeks to provide a comprehensive perspective on these issues and promote the development of novel therapeutic strategies. Researchers are encouraged to submit original research articles, reviews, and general reviews that contribute to advancing the field and addressing these critical questions.

To gather further insights into the metabolism and immune microenvironment of hematological malignancies, we welcome articles addressing, but not limited to, the following themes:
- Unique metabolic changes and regulatory mechanisms of hematological malignant tumor cells and immune cells.
- Interaction between immune cells and hematological malignant tumor cells.
- Influence of hematological malignancy metabolism on immunotherapy.
- Regulation of metabolism and immune response of hematological malignancies by microenvironmental factors.
- The relationship between metabolism and immune escape in hematological malignancies.
- Application of novel therapeutic strategies and drugs in the metabolism and immune microenvironment of hematological malignancies.

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Frontiers in Cell and Developmental Biology

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