Mechanical factors play an important role in bone and joint disorders or repair and are a therapeutic focus of almost all degenerative diseases such as osteoarthritis and spinal degeneration. Mechanical signaling is an important mediator of numerous physiological and pathophysiological processes in the cells and tissues of the musculoskeletal system, including cartilage metabolism and bone remodeling. Novel biomaterials endowed with goal-oriented mechanical properties are also the frontier in the field of bone tissue engineering and cartilage tissue engineering. Furthermore, the quantitative study of mechanical issues in bone and orthopedic surgery, utilizing biomechanical principles and methods, holds vast and profound applicative prospects.

The aim of this research topic is to explore the latest advancements in the cross-cutting fields of musculoskeletal biomechanics, biomaterials, and orthopedic surgery in the context of bone and joint disorders. These advancements are anticipated to shed light on new disease targets and pathogenic mechanisms, as well as provide novel biomaterials with tailored mechanical properties that hold promise for tissue engineering applications. Advanced surgical techniques or implant modifications in the field of orthopedics, based on biomechanical experimental evidence, are also highly encouraged in this special issue. These advancements hold great potential in enhancing the outcomes of orthopedic diseases by leveraging the principles of biomechanics and incorporating evidence-based approaches.

In this Research Topic, we welcome researchers to submit Original Research and Systematic Reviews focusing on but not limited to the following topics:
1. The mechanisms of mechanical signaling in regulating cellular functions in degenerative diseases of bone and joints.
2. Emerging understanding of biomechanical characteristics in orthopedic techniques or implants based on mechanical experiments and finite element analysis.
3. The multidirectional effects of factors such as physical activity and weight-bearing in the degeneration and repair of bones and joints
4. Application of novel technologies based on biomechanical improvements in orthopedic surgeries.
5. Advances in regenerative medicine therapy (e.g. bioactive materials, stem cell and PRP) for the treatment of musculoskeletal disorders.
6. Biomechanics based innovative applications of artificial intelligence assisted diagnosis and surgery in bone and joint diseases.

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Frontiers in Bioengineering and Biotechnology

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