"A Year in Review: Discussions in RNA” is part of a wider series of Research Topics across Frontiers in Genetics.

This Research Topic aims to spark discussions around some of the most developing areas in the RNA field. This field is continuously evolving; therefore, we are seeking to understand developments and perspectives on themes represented by articles that have attracted attention throughout the year.

The chosen manuscripts are:

1. Small Open Reading Frames, How to Find Them and Determine Their Function.

2. Cuproptosis-Related lncRNAs are Biomarkers of Prognosis and Immune Microenvironment in Head and Neck Squamous Cell Carcinoma.

3. Emerging Role of Exosomal Long Non-coding RNAs in Spaceflight-Associated Risks in Astronauts.

4. The Role of Alternative Polyadenylation in the Regulation of Subcellular RNA Localization.

5. The prognostic value and immune landscape of a cuproptosis-related lncRNA signature in head and neck squamous cell carcinoma.

6. Integrative analysis of the expression profiles of whole coding and non-coding RNA transcriptomes and construction of the competing endogenous RNA networks for chronic obstructive pulmonary disease.

7. Features of CFTR mRNA and implications for therapeutics development.

8. A novel signature combing cuproptosis- and ferroptosis-related genes in sepsis-induced cardiomyopathy.

We welcome Opinions, Perspectives, Hypotheses and Theory, Mini-Reviews and Original Research article types on themes such as:

- Small open reading frames
- The role of lncRNAs
- RNAs in extracellular vesicles
- The regulation of subcellular RNA localization
- RNA as diagnostic markers
- RNA regulatory networks
- RNA-based and RNA-targeted therapies

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Frontiers in Genetics

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