Mitochondrial, commonly known as the “powerhouse of the cell,” is also the site of final oxidation of substances such as sugars, fats, and amino acids to release energy. Mitochondrial metabolism and functions are essential for tumorigenesis and play important roles in multiple immune pathways. Cancer cells can suppress anti-tumor immune responses or evade immune surveillance by competing for and consuming essential nutrients or otherwise reducing the metabolic fitness of tumor-infiltrating immune cells. Additionally, the remodeling of immune cells' mitochondrial metabolism affects their function, impacting the anti-tumor immune responses. Therefore, exploring the crosstalk between mitochondrial metabolism and tumor immunity can improve the low response rates typically achieved with immunotherapy.
To investigate the relationship between mitochondrial metabolism and tumor immunity, and develop therapies that target mitochondrial metabolism and restore antitumor immune activity. This will involve exploring which mitochondrial functions can impact the tumor immune microenvironment, identifying immune cell populations that drive antitumor immune responses due to mitochondrial dysfunction, and examining how mitochondrial metabolism affects the function of immune cells in regulating their immune resistance.
The research topic focuses on the relationship between mitochondrial function and antitumor immunity. The authors may explore how mitochondrial metabolism affects the antitumor response, identify the immune cell populations affected by mitochondrial metabolism reprogramming, and assess changes in their antitumor activity.
Keywords:
mitochondrial metabolism, tumor immunity, tumor microenvironment, antitumor response, immunosurveillance
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
Mitochondrial, commonly known as the “powerhouse of the cell,” is also the site of final oxidation of substances such as sugars, fats, and amino acids to release energy. Mitochondrial metabolism and functions are essential for tumorigenesis and play important roles in multiple immune pathways. Cancer cells can suppress anti-tumor immune responses or evade immune surveillance by competing for and consuming essential nutrients or otherwise reducing the metabolic fitness of tumor-infiltrating immune cells. Additionally, the remodeling of immune cells' mitochondrial metabolism affects their function, impacting the anti-tumor immune responses. Therefore, exploring the crosstalk between mitochondrial metabolism and tumor immunity can improve the low response rates typically achieved with immunotherapy.
To investigate the relationship between mitochondrial metabolism and tumor immunity, and develop therapies that target mitochondrial metabolism and restore antitumor immune activity. This will involve exploring which mitochondrial functions can impact the tumor immune microenvironment, identifying immune cell populations that drive antitumor immune responses due to mitochondrial dysfunction, and examining how mitochondrial metabolism affects the function of immune cells in regulating their immune resistance.
The research topic focuses on the relationship between mitochondrial function and antitumor immunity. The authors may explore how mitochondrial metabolism affects the antitumor response, identify the immune cell populations affected by mitochondrial metabolism reprogramming, and assess changes in their antitumor activity.
Keywords:
mitochondrial metabolism, tumor immunity, tumor microenvironment, antitumor response, immunosurveillance
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.