Phosphate management is a complex interplay between cellular function and multicellular systems within the human body, encompassing about 1% of the total body weight, predominantly present in bones and teeth. A smaller proportion embeds itself in cellular membranes, nucleic acids, and signaling entities, underscoring its critical function. Hormonal regulation involving agents like parathyroid hormone, 25 hydroxyvitamin D, and fibroblast-growth-factor-23 primarily operates across pivotal physiological platforms—the gastrointestinal tract, skeletal storage, and renal excretion. This hormone-mediated orchestration addresses phosphate equilibrium but also presents the capacity for dysfunction.

This Research Topic aims to deepen the understanding of phosphate disorders stemming from a medley of human, animal, and cellular discrepancies, emphasizing the pathophysiological underpinnings of phosphate imbalances. Clinical investigations will dissect the ramifications of hypo- and hyperphosphatemia on health, while translational studies enrich these findings, probing the interplays of phosphate and its hormonal conduits in non-human models. This bifurcated approach seeks not only to validate clinical observations but also to frame them within a broader biological context, offering a robust translational bridge.

The scope of submissions is deliberately broad yet pointed, focused on dissecting and interpreting defective phosphate metabolism influenced by varied conditions—genetic anomalies, acute interventions, and chronic impairments. We encourage submissions across several specific areas, set to explore the full gamut of phosphate's role in health and disease:

- Chronic kidney disease
- Hyper/hypophosphatemia and related wasting disorders
- Bone health, including osteomalacia and rickets
- Phosphate processing in the gastrointestinal tract
- Vitamin D deficiency
- Regulatory roles of phosphatonins and their pathways
- Parathyroid hormone and parathyroid hormone-related protein conditions
- Contributions of hydroxyapatite and phosphate in nucleotide biology
- Impacts of nutritional strategies on phosphate balance

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Frontiers in Endocrinology

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