About this Research Topic
Phosphate is an essential electrolyte in the human body, constituting about 1% of the total body weight. Of this, 85% lies in bones and teeth. The remaining is distributed in other tissues where it constitutes cell membranes, nucleic acids, high-energy phosphate esters and cellular signalling systems. Given its essential role, multiple hormones - including parathyroid hormone, 25 hydroxyvitamin D, fibroblast-growth-factor-23 and other phosphatonins - contribute to phosphate regulation. These hormones act on three physiological systems: the gut, by regulating its absorption; the bone, by its storage; and the kidney by phosphate excretion.
The present Research Topic aims to collect evidence of phosphate disorders in humans, animal models and at the cellular level to highlight the pathophysiological dysfunctions caused by phosphate imbalances through a clinical and translational approach. The clinical papers will focus on the consequences of hypo/hyperphosphatemia and impaired regulation of mediators on multiple aspects of human health. Conversely, the translational collection will examine outcomes produced by phosphate and its hormonal regulation on animal and/or cellular models, thereby supporting clinical observations.
Together, these will offer new perspectives on the intricate regulation of phosphate metabolism and on the effects of diseases characterized by defective phosphate regulation on human health.
This Research Topic will cover papers on clinical conditions that exhibit defective phosphate metabolism, ranging from genetic to acute/chronic acquired conditions, and will be addressed to various specialty themes such as endocrinology, nephrology, and nutritional science. Additionally, the translational papers will focus on any cellular or metabolic process involving phosphate or phosphatonins pathways.
The topic will cover (but is not limited to) the following themes:
• Chronic kidney disease;
• Hyper and/or hypophosphatemia;
• Phosphate wasting disorders;
• Osteomalacia and/or rickets;
• Bone disorders;
• Gastrointestinal phosphate handling
• parathyroid hormone, 25 hydroxyvitamin D, fibroblast-growth-factor-23 and other phosphatonins;
• Hydroxyapatite;
• Nucleic acids, adenosine triphosphate, cyclic-adenosine monophosphate;
• Nutritional intervention.
The present Research Topic aims to collect evidence of phosphate disorders in humans, animal models and at the cellular level to highlight the pathophysiological dysfunctions caused by phosphate imbalances through a clinical and translational approach. The clinical papers will focus on the consequences of hypo/hyperphosphatemia and impaired regulation of mediators on multiple aspects of human health. Conversely, the translational collection will examine outcomes produced by phosphate and its hormonal regulation on animal and/or cellular models, thereby supporting clinical observations.
Together, these will offer new perspectives on the intricate regulation of phosphate metabolism and on the effects of diseases characterized by defective phosphate regulation on human health.
This Research Topic will cover papers on clinical conditions that exhibit defective phosphate metabolism, ranging from genetic to acute/chronic acquired conditions, and will be addressed to various specialty themes such as endocrinology, nephrology, and nutritional science. Additionally, the translational papers will focus on any cellular or metabolic process involving phosphate or phosphatonins pathways.
The topic will cover (but is not limited to) the following themes:
• Chronic kidney disease;
• Hyper and/or hypophosphatemia;
• Phosphate wasting disorders;
• Osteomalacia and/or rickets;
• Bone disorders;
• Gastrointestinal phosphate handling
• parathyroid hormone, 25 hydroxyvitamin D, fibroblast-growth-factor-23 and other phosphatonins;
• Hydroxyapatite;
• Nucleic acids, adenosine triphosphate, cyclic-adenosine monophosphate;
• Nutritional intervention.
Keywords: bone metabolism, cardiovascular endocrinology, phosphate handling, phosphate disorders, osteomalacia
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
