Splicing events include constitutive splicing, alternative splicing, and trans-splicing. Alternative splicing encompasses exon skipping, mutually exclusive exons, alternative splice sites, intron retention, and exon extension or shortening. Regulation of splicing events is mediated by multiple splicing factors and regulatory elements, such as splicing enhancers and silencers. These components interact with specific RNA-binding proteins to regulate spliceosome assembly and influence splicing decisions.

The inflammatory response is a rapid and efficient defense mechanism of the body's immune system against various stressors, injuries, and infections. This process involves complex interactions among various immune cells. When the inflammatory response is prolonged or excessively activated, it can form the pathological basis of various diseases. The differentiation and function of immune cells largely depend on precise splicing events. For instance, the diversity of antigen receptor genes in T cells and B cells, which forms the basis of adaptive immune responses, is generated through complex splicing and recombination processes. Aberrant splicing events can lead to dysregulated inflammatory responses, promoting chronic inflammation and inflammation-related diseases. In summary, understanding the intricate interactions between splicing mechanisms and inflammation is crucial for developing new anti-inflammatory therapeutic strategies.

The objective of this topic is to present a thorough synthesis of the contemporary comprehension of splicing events and their therapeutic implications in inflammatory diseases. By consolidating the latest research findings, this exploration seeks to deepen our understanding of the significance of splicing in inflammation and to stimulate the development of innovative therapeutic approaches that address splicing dysregulation. The ultimate aim is to harness the potential of splicing modulation as a therapeutic strategy to effectively manage and treat inflammatory conditions, thereby improving patient outcomes and advancing the field of inflammation research.

This research topic invites submissions of original research articles, review articles, and perspectives that delve into splicing events in various inflammatory diseases. Topics of interest encompass, but are not restricted to:

1. Molecular mechanisms underlying splicing dysregulation in chronic inflammatory conditions, such as rheumatoid arthritis, inflammatory bowel disease, and asthma.
2. The identification and characterization of splicing isoforms associated with inflammatory diseases.
3. The functional implications of splicing variations on the development, activation, and inflammatory responses of immune cells.
4. Innovative therapeutic strategies that target splicing events for the management of inflammatory diseases.
5. The potential of splicing events as biomarkers and their diagnostic/prognostic applications in inflammation research.

Manuscript Types: We welcome a variety of contributions, including Original Research, Reviews, Mini-Reviews, Perspectives, Case Reports, and Opinion articles. Submissions should aim to expand our understanding in this vital area and can cover experimental, clinical, or theoretical dimensions of splicing events in inflammation.

Bioinformatics or Computational Analysis of public genome or transcriptome databases that are not accompanied by robust and relevant experimental validation, for instance in patients or by PCR, are out of scope for this journal.
Manuscripts describing the pharmacological action of drugs used in traditional medicine in models of disease are not in scope unless they have a very strong focus on the immune system.

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Frontiers in Immunology

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