Transient Receptor Potential (TRP) channels constitute a diverse family of ion channels found in various cell types and tissues throughout the body. These channels play crucial roles in mediating sensory transduction, cellular signaling, and homeostatic regulation. Importantly, TRP channels have emerged as promising therapeutic targets for a wide range of diseases, including chronic pain, inflammation, neurodegenerative disorders, and cardiovascular conditions. Understanding the pharmacology of TRP channels is essential for elucidating their physiological functions and exploring their therapeutic potential. This Research Topic aims to gather state-of-the-art research on TRP channels, with a focus on pharmacological insights into their modulation, molecular mechanisms, and therapeutic applications.

In this Research Topic, we welcome articles focusing on:

Pharmacological modulation of TRP channel activity in different disease states.

Molecular mechanisms underlying the function and regulation of TRP channels.

Therapeutic applications of targeting TRP channels in chronic pain management.

TRP channel involvement in inflammatory processes and potential therapeutic interventions.

Neurodegenerative disorders and the role of TRP channels as therapeutic targets.

Cardiovascular conditions and the pharmacological targeting of TRP channels for treatment.

Novel pharmacotherapeutic approaches targeting specific TRP channel subtypes.

Clinical trials investigating the efficacy and safety of TRP channel modulators in various diseases.

Drug development strategies focusing on TRP channels as potential targets for new therapeutics.

Pharmacokinetic and pharmacodynamic considerations in the development of TRP channel modulators.

These articles will contribute to advancing our understanding of TRP channel pharmacology, elucidating their roles in health and disease, and fostering the development of novel therapeutic interventions targeting TRP channels. We welcome a variety of article types, including under the following categories: Original Research, Review, Mini Review, Brief Research Report, and Perspective.

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Frontiers in Pharmacology

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