About this Research Topic
Communication between metabolic tissues such as adipose tissue and the liver plays a crucial role in maintaining metabolic homeostasis. However, the specific signalling pathways and regulatory mechanisms involved in this communication are not fully understood. In addition, the role of gut microbiota in metabolic diseases is actively studied, acting as an endocrine organ. There is growing evidence of bidirectional communication between gut microbiota and host cells in regulating metabolic health. However, there is a need for further investigation into specific microbial populations, their functions, and how they interact with host metabolism.
Furthermore, it has been proposed a crosstalk between reproductive tissues and metabolic signalling. It is known that the metabolic status impacts reproduction and early life development.
Nonetheless, the extent to which metabolic status impacts fertility and condition development, and even adult health, is still a matter of study.
Further research is imperative to enhance our understanding of these processes and develop targeted interventions for metabolic disorders.
This Research Topic aims to address the urgent challenge of metabolic diseases, which are major contributors to health complications and mortality worldwide. Over the past decade, there has been a significant increase in the prevalence of metabolic disorders, including obesity and related comorbidities, certain types of cancer, Type 2 Diabetes (T2D), metabolic associated fatty liver diseases (MAFLD),
Metabolic Syndrome, and endocrine disorders related to metabolic diseases such as Polycystic ovary syndrome and Gestational Diabetes.
Given the complexity of metabolic and chronic diseases, there is a need for a better comprehension of their etiology and development, considering the relationships among organs, systems and organisms with their environment. Furthermore, increasing attention has been given to the effects of the maternal environment on the offspring development and its potential impact on postnatal health outcomes, thus highlighting the importance of organisms’ communication from early developmental stages. Understanding the complexities of inter-tissues and inter-kingdom communication is crucial for unravelling the pathophysiology of metabolic diseases and developing targeted therapeutic interventions.
This special issue aims to present the advances regarding metabolic alterations etiology, prevention and treatment considering basic, epidemiological and clinical research focusing on new perspectives that take into account communication and crosstalk between organisms, tissues and environment.
This issue explores into the complex realm of metabolic alterations, a leading cause of health complications and mortality. Despite their prevalence, the underlying causes and progression of these conditions remain incompletely understood. Novel perspectives that explore the intricate communication networks between tissues and organisms, particularly throughout development, are pivotal for unravelling the pathophysiology of metabolic diseases and devising targeted therapeutic strategies. Author Information:
We invite contributions from researchers, clinicians, and experts in fields such as physiology, epidemiology, microbiology, and endocrinology. Manuscript types include original research, reviews, mini-reviews, brief reports, and other article types. Topics of interest span a wide array, encompassing:
• Developmental programming effects on metabolic health
• Role of microbiota on metabolic alterations development, progression and management
• Interplay between gut microbiota and host cells in metabolic health
• Environmental contributions to metabolic health
• Adipose tissue-liver crosstalk
• Hepato-gonadal axes in fertility related-metabolic diseases
• Gut-gonadal axes in metabolic and endocrine disorders
• Therapeutic interventions
Furthermore, it has been proposed a crosstalk between reproductive tissues and metabolic signalling. It is known that the metabolic status impacts reproduction and early life development.
Nonetheless, the extent to which metabolic status impacts fertility and condition development, and even adult health, is still a matter of study.
Further research is imperative to enhance our understanding of these processes and develop targeted interventions for metabolic disorders.
This Research Topic aims to address the urgent challenge of metabolic diseases, which are major contributors to health complications and mortality worldwide. Over the past decade, there has been a significant increase in the prevalence of metabolic disorders, including obesity and related comorbidities, certain types of cancer, Type 2 Diabetes (T2D), metabolic associated fatty liver diseases (MAFLD),
Metabolic Syndrome, and endocrine disorders related to metabolic diseases such as Polycystic ovary syndrome and Gestational Diabetes.
Given the complexity of metabolic and chronic diseases, there is a need for a better comprehension of their etiology and development, considering the relationships among organs, systems and organisms with their environment. Furthermore, increasing attention has been given to the effects of the maternal environment on the offspring development and its potential impact on postnatal health outcomes, thus highlighting the importance of organisms’ communication from early developmental stages. Understanding the complexities of inter-tissues and inter-kingdom communication is crucial for unravelling the pathophysiology of metabolic diseases and developing targeted therapeutic interventions.
This special issue aims to present the advances regarding metabolic alterations etiology, prevention and treatment considering basic, epidemiological and clinical research focusing on new perspectives that take into account communication and crosstalk between organisms, tissues and environment.
This issue explores into the complex realm of metabolic alterations, a leading cause of health complications and mortality. Despite their prevalence, the underlying causes and progression of these conditions remain incompletely understood. Novel perspectives that explore the intricate communication networks between tissues and organisms, particularly throughout development, are pivotal for unravelling the pathophysiology of metabolic diseases and devising targeted therapeutic strategies. Author Information:
We invite contributions from researchers, clinicians, and experts in fields such as physiology, epidemiology, microbiology, and endocrinology. Manuscript types include original research, reviews, mini-reviews, brief reports, and other article types. Topics of interest span a wide array, encompassing:
• Developmental programming effects on metabolic health
• Role of microbiota on metabolic alterations development, progression and management
• Interplay between gut microbiota and host cells in metabolic health
• Environmental contributions to metabolic health
• Adipose tissue-liver crosstalk
• Hepato-gonadal axes in fertility related-metabolic diseases
• Gut-gonadal axes in metabolic and endocrine disorders
• Therapeutic interventions
Keywords: Metabolic diseases; Endocrine disorders; Inter-kingdom communication; Tissues, organ and systems crosstalk; Developmental programming
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
