About this Research Topic
“Unconventional” T cells include mucosal-associated invariant T (MAIT) cells, γδ T cells, intestinal intraepithelial lymphocytes (IELs), and invariant natural killer T (iNKT) cells. Unlike the classical conventional αβ T cells, these “unconventional” or “innate-like” T cells are non-recirculating residents of non-lymphoid tissues and organs and exhibit features of both innate and adaptive immunity. These lymphocyte subsets express T cell receptors (TCRs) of limited diversity and exert immune effector functions by generating large amounts of cytokines rapidly.
Certain unconventional T cells dominate as immune cells in epithelium and are involved in infection and autoimmunity. Recent studies have uncovered new and fascinating roles for these unconventional T cells in maintaining tissue integrity, conducting tissue repair, regulating inflammation, and providing immune protection. The recruitment of lymphocytes to target tissues has been shown to play a critical role in the pathogenesis of inflammatory skin diseases, such as psoriasis, and oral mucosal diseases, such as oral lichen planus.
This Research Topic aims to provide an in-depth understanding of the molecular mechanisms underlying unconventional T cells-mediated inflammatory skin and oral mucosal diseases, which include psoriasis, graft-versus-host disease, lupus erythematosus, lichen planus, oral lichenoid lesions, skin and oral mucosal infection, skin wound healing, among others.
We welcome submissions of Brief Research Reports, Editorials, Hypothesis & Theory articles, Mini Reviews, Original Research articles, Reviews, and Systematic Reviews on the following subtopics, which include, but are not limited to:
• Mechanisms of unconventional T cells-mediated inflammatory skin diseases;
• Mechanisms of unconventional T cells-mediated oral mucosal diseases;
• Mechanisms of unconventional T cells in skin wound healing;
• Research on current and future prevention and therapeutic strategies.
Certain unconventional T cells dominate as immune cells in epithelium and are involved in infection and autoimmunity. Recent studies have uncovered new and fascinating roles for these unconventional T cells in maintaining tissue integrity, conducting tissue repair, regulating inflammation, and providing immune protection. The recruitment of lymphocytes to target tissues has been shown to play a critical role in the pathogenesis of inflammatory skin diseases, such as psoriasis, and oral mucosal diseases, such as oral lichen planus.
This Research Topic aims to provide an in-depth understanding of the molecular mechanisms underlying unconventional T cells-mediated inflammatory skin and oral mucosal diseases, which include psoriasis, graft-versus-host disease, lupus erythematosus, lichen planus, oral lichenoid lesions, skin and oral mucosal infection, skin wound healing, among others.
We welcome submissions of Brief Research Reports, Editorials, Hypothesis & Theory articles, Mini Reviews, Original Research articles, Reviews, and Systematic Reviews on the following subtopics, which include, but are not limited to:
• Mechanisms of unconventional T cells-mediated inflammatory skin diseases;
• Mechanisms of unconventional T cells-mediated oral mucosal diseases;
• Mechanisms of unconventional T cells in skin wound healing;
• Research on current and future prevention and therapeutic strategies.
Keywords: mucosal-associated invariant T cells, γδ T cells, invariant natural killer T cells, intestinal intraepithelial lymphocytes, inflammatory skin diseases, oral mucosal diseases
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
